Overview
- Reports on research in biomarkers of aging across molecular, cellular, immunological, and neurological factors
- Covers genetics and epigenetic aging markers, immunosenescence and inflammaging markers, and biological markers of aging and mortality
- Benefits researchers, practitioners and advanced students who work with biomarkers
Part of the book series: Healthy Ageing and Longevity (HAL, volume 10)
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Table of contents (23 chapters)
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Front Matter
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Biomarkers of Aging and Health
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Front Matter
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Proteomics and Glycomics Biomarkers of Aging
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Front Matter
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Genetics and Epigenetics Aging Markers
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Front Matter
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Immunosenescence and Inflammaging Markers
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Front Matter
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Keywords
About this book
This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.
In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).
The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.
Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.
Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Biomarkers of Human Aging
Editors: Alexey Moskalev
Series Title: Healthy Ageing and Longevity
DOI: https://doi.org/10.1007/978-3-030-24970-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-24969-4Published: 24 September 2019
Softcover ISBN: 978-3-030-24972-4Published: 24 September 2020
eBook ISBN: 978-3-030-24970-0Published: 13 September 2019
Series ISSN: 2199-9007
Series E-ISSN: 2199-9015
Edition Number: 1
Number of Pages: VII, 421
Number of Illustrations: 5 b/w illustrations, 34 illustrations in colour
Topics: Biogerontology, Molecular Medicine, Human Physiology, Immunology