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Cardiac Repolarization

Basic Science and Clinical Management

  • Book
  • © 2020

Overview

Editors:
  1. Nabil El-Sherif

    1. Department of Medicine and Physiology, State University of New York Downstate Medical Center, VA New York Harbor Healthcare Center, Brooklyn, USA

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  • Examines pathophysiology, molecular biology, and clinical aspects of cardiac repolarization

  • Highlights clinical management of Long QT syndrome, early repolarization syndrome, and arrhythmias

  • Discusses the future of pharmacotherapeutics, stem cell therapy, and genetic therapy

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
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  2. Pathophysiology, Molecular Biology, and Clinical Aspects of Cardiac Repolarization

    1. Front Matter

      Pages 1-1
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    2. Physiology and Molecular Biology of Ion Channels Underlying Ventricular Repolarization of the Mammalian Heart

      • Thomas W. Comollo, Chuangeng Zhang, Xinle Zou, Robert S. Kass
      Pages 3-47

    3. Neuromodulation of Cardiac Repolarization and Arrhythmogenesis

      • Fabrice Extramiana, Pierre Maison-Blanche
      Pages 49-76

    4. Repolarization Remodeling in Structural Heart Disease

      • Andreas S. Barth, Gordon F. Tomaselli
      Pages 77-85

    5. Cardiac Repolarization and Stem Cells: An Emerging Path Toward Precision Medicine

      • Massimiliano Gnecchi, Luca Sala, Peter J. Schwartz
      Pages 87-107

    6. Role of Late Sodium Current During Repolarization and Its Pathophysiology

      • Mohamed Chahine
      Pages 109-117

    7. Age, Sex and Racial Differences in Cardiac Repolarization and Arrhythmogenesis

      • Arja Suzanne Vink, Sally-Ann B. Clur, Pieter G. Postema, Nico A. Blom, Arthur A. M. Wilde
      Pages 119-129

    8. ECG-Derived Evaluation of Cardiac Repolarization

      • Gioia Turitto, Nabil El-Sherif
      Pages 131-138

  3. Pathophysiology, Molecular Biology, and Clinical Aspects of Long QT Syndromes

    1. Front Matter

      Pages 139-139
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    2. Genotype-Phenotype Correlation in Congenital LQTS: Implications for Diagnosis and Risk Stratification

      • Ilan Goldenberg
      Pages 141-164

    3. Clinical Management of LQTS Patients

      • Wojciech Zareba
      Pages 165-184

    4. Drug-Induced Long QT Syndrome and Torsades de Pointes

      • Raymond L. Woosley, Peter J. Schwartz
      Pages 185-200

    5. Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes

      • Nabil El-Sherif, Gioia Turitto, Mohamed Boutjdir
      Pages 201-216

    6. Pathogenesis of Autoimmune-Associated Long QT Syndrome

      • Mohamed Boutjdir, Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Nabil El-Sherif
      Pages 217-226

    7. The Role of Inflammation and Autoimmunity in Long QT Syndrome

      • Pietro Enea Lazzerini, Franco Laghi-Pasini, Nabil El-Sherif, Mohamed Boutjdir, Pier Leopoldo Capecchi
      Pages 227-251

  4. Pathophysiology, Molecular Biology, and Clinical Aspects of Early Repolarization Syndromes

    1. Front Matter

      Pages 253-253
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    2. Genetics, Molecular Biology, and Emerging Concepts of Early Repolarization Syndrome

      • Charles Antzelevitch, Gregory Dendramis
      Pages 255-268

    3. Electrocardiographic J Wave and Cardiovascular Risk in the General Population

      • Heikki V. Huikuri
      Pages 269-276

    4. Benign Versus Malignant Early Repolarization Patterns

      • Raphael Rosso, Sami Viskin
      Pages 277-283
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Keywords

About this book

This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.


Editors and Affiliations

  • Department of Medicine and Physiology, State University of New York Downstate Medical Center, VA New York Harbor Healthcare Center, Brooklyn, USA

    Nabil El-Sherif

About the editor

Nabil El-Sherif, MD
Professor of Medicine & Physiology, State University of New York Medical Center
Chief, Cardiology Division, NY Harbor VA Healthcare System, Brooklyn, NY
Distinguished Scientist of the American College of Cardiology

Bibliographic Information

  • Book Title: Cardiac Repolarization

  • Book Subtitle: Basic Science and Clinical Management

  • Editors: Nabil El-Sherif

  • DOI: https://doi.org/10.1007/978-3-030-22672-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-22671-8Published: 26 September 2019

  • Softcover ISBN: 978-3-030-22674-9Published: 26 September 2020

  • eBook ISBN: 978-3-030-22672-5Published: 29 August 2019

  • Edition Number: 1

  • Number of Pages: XV, 354

  • Number of Illustrations: 39 b/w illustrations, 61 illustrations in colour

  • Topics: Cardiology

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