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Bile Acids and Their Receptors

  • Book
  • © 2019

Overview

Editors:
  1. Stefano Fiorucci

    1. University of Perugia, School of Medicine, Perugia, Italy

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  2. Eleonora Distrutti

    1. S.C. Gastroenterologia, Azienda Ospedaliera di Perugia, Perugia, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Gives an overview on latest findings in the novel field of research of bile acids as signaling molecules
  • Offers a cross-country view of the functional role of bile acids as signaling molecules, virtuallyacting on all major areas of metabolism
  • Describes different approaches of bile acids pharmacology by providing authors' diverse perspectives

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 256)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The Pharmacology of Bile Acids and Their Receptors

    • Stefano Fiorucci, Eleonora Distrutti
    Pages 3-18

  3. Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors

    • Verena Keitel, Jan Stindt, Dieter Häussinger
    Pages 19-49

  4. Bile Acid-Activated Receptors: A Review on FXR and Other Nuclear Receptors

    • Dong-Ju Shin, Li Wang
    Pages 51-72

  5. The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism

    • Marica Cariello, Marilidia Piglionica, Raffaella Maria Gadaleta, Antonio Moschetta
    Pages 73-93

  6. Signaling from Intestine to the Host: How Bile Acids Regulate Intestinal and Liver Immunity

    • Michele Biagioli, Adriana Carino
    Pages 95-108

  7. Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators

    • Francesco Saverio Di Leva, Daniele Di Marino, Vittorio Limongelli
    Pages 111-136

  8. Chemistry and Pharmacology of GPBAR1 and FXR Selective Agonists, Dual Agonists, and Antagonists

    • Simona De Marino, Carmen Festa, Valentina Sepe, Angela Zampella
    Pages 137-165

  9. Nonsteroidal FXR Ligands: Current Status and Clinical Applications

    • Christian Gege, Eva Hambruch, Nina Hambruch, Olaf Kinzel, Claus Kremoser
    Pages 167-205

  10. Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease

    • Tim van Zutphen, Anna Bertolini, Hilde D. de Vries, Vincent W. Bloks, Jan Freark de Boer, Johan W. Jonker et al.
    Pages 207-234

  11. UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications

    • Daniel Cabrera, Juan Pablo Arab, Marco Arrese
    Pages 237-264

  12. Chenodeoxycholic Acid: An Update on Its Therapeutic Applications

    • Stefano Fiorucci, Eleonora Distrutti
    Pages 265-282

  13. Obeticholic Acid: An Update of Its Pharmacological Activities in Liver Disorders

    • Stefano Fiorucci, Cristina Di Giorgio, Eleonora Distrutti
    Pages 283-295

  14. Targeting FXR in Cholestasis

    • Verena Keitel, Carola Dröge, Dieter Häussinger
    Pages 299-324

  15. Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis

    • Justin D. Schumacher, Grace L. Guo
    Pages 325-357

  16. Targeting Bile Acid-Activated Receptors in Bariatric Surgery

    • Lili Ding, Zhipeng Fang, Yanjun Liu, Eryun Zhang, Tracy Huang, Li Yang et al.
    Pages 359-378
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Keywords

About this book

This book focusses on the latest results related to the field of  bile acids as signaling molecules  and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR  and GPBAR1 are essential bile acid sensors that  integrate the de novo bile acid synthesis with intestinal microbiota and  liver metabolism, in a broader sense,  BARs  play a pathogenic role in the development of common human alignments  including  liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. 

Editors and Affiliations

  • University of Perugia, School of Medicine, Perugia, Italy

    Stefano Fiorucci

  • S.C. Gastroenterologia, Azienda Ospedaliera di Perugia, Perugia, Italy

    Eleonora Distrutti

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