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  • Reference work
  • © 2022

Peripheral Nerve Tissue Engineering and Regeneration

  • Comprehensive overview of all the key technologies developed for current and future nerve repair
  • Translational perspective links basic scientific knowledge with clinical application
  • Introduction includes the first published detailed historical perspective of nerve research

Part of the book series: Reference Series in Biomedical Engineering (RSBE)

Part of the book sub series: Tissue Engineering and Regeneration (TIENRE)

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Table of contents (19 entries)

  1. Front Matter

    Pages i-xvi
  2. The History of Nerve Repair

    • Susan Standring
    Pages 1-32
  3. The Peripheral Nerve Repair Environment

    1. Front Matter

      Pages 33-33
    2. Blood Supply and Microcirculation of the Peripheral Nerve

      • Cosima Prahm, Johannes Heinzel, Jonas Kolbenschlag
      Pages 35-79
    3. The Immune Response and Implications for Nerve Repair

      • Victoria H. Roberton
      Pages 81-109
    4. Autonomic Nervous System Repair and Regeneration

      • Luisa Muratori, Federica Fregnan, Giacomo Carta, Stefano Geuna
      Pages 111-130
  4. Models and Evaluation of Peripheral Nerve Regeneration

    1. Front Matter

      Pages 131-131
    2. Appropriate Animal Models for Translational Nerve Research

      • Kirsten Haastert-Talini
      Pages 133-149
    3. Basic Nerve Histology and Histological Analyses Following Peripheral Nerve Repair and Regeneration

      • Jesús Chato-Astrain, Óscar D. García-García, Fernando Campos, David Sánchez-Porras, Víctor Carriel
      Pages 151-187
    4. Mathematical Modeling for Nerve Repair Research

      • Simão Laranjeira, Rachel Coy, Rebecca J. Shipley
      Pages 189-241
  5. Biomaterials for Peripheral Nerve Regeneration

    1. Front Matter

      Pages 243-243
    2. Biomaterials and Scaffolds for Repair of the Peripheral Nervous System

      • Caroline S. Taylor, John W. Haycock
      Pages 245-279
    3. Fibrin in Nerve Tissue Engineering

      • Johannes Heinzel, Matthias Gloeckel, Andreas Gruber, Philipp Heher, David Hercher
      Pages 281-322
    4. Silk Biomaterials in Peripheral Nerve Tissue Engineering

      • Flavia Millesi, Tamara Weiss, Christine Radtke
      Pages 323-351
    5. Collagen Biomaterials for Nerve Tissue Engineering

      • Despoina Eleftheriadou, James B. Phillips
      Pages 353-382
  6. Therapeutic Options for Peripheral Nerve Regeneration

    1. Front Matter

      Pages 383-383
    2. Schwann Cells in Nerve Repair and Regeneration

      • Kristjan R. Jessen, Rhona Mirsky
      Pages 385-401
    3. Therapeutic Cells and Stem Cells for Nerve Regeneration

      • Krisztián Pajer, Antal Nógrádi
      Pages 403-414
    4. Extracellular Vesicles for Nerve Regeneration

      • Gustav Andersson, Paul J. Kingham
      Pages 415-435
    5. Drug Therapies for Peripheral Nerve Injuries

      • Melissa L. D. Rayner, Jess Healy, James B. Phillips
      Pages 437-463

About this book

This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.
The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. 
The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.

Editors and Affiliations

  • UCL Centre for Nerve Engineering, Department of Pharmacology UCL School of Pharmacy University College London, London, UK

    James B. Phillips

  • Ludwig Boltzmann Institute for Traumatology in coop. with AUVA, Department Life Science Engineering, Austrian Cluster for Tissue Regeneration, University of Applied Sciences TechnikumWien, Vienna, Austria

    David Hercher

  • Ludwig Boltzmann Institute for Traumatology in coop. with AUVA, Austrian Cluster for Tissue Regeneration, AUVA Unfallkrankenhaus Lorenz Böhler, Vienna, Austria

    Thomas Hausner

About the editors

James B. Phillips is Professor of Regenerative Medicine and Vice Dean (Innovation and Enterprise) in the Faculty of Life Sciences at University College London. He is also co-Director of the UCL Centre for Nerve Engineering and Chief Scientific Officer of the UCL spinout company Glialign Ltd. His research focus on translational neuroscience includes construction of living artificial tissues for regenerative medicine; developing novel cell, drug, gene, and biomaterial therapies for neural repair and protection; and advanced 3D co-culture models. Applications include treating and modeling neurodegenerative diseases and traumatic injury to peripheral nerves, the spinal cord, and the brain. His multi-disciplinary research group is based in the Department of Pharmacology at the UCL School of Pharmacy, and uses in silico, in vitro, in vivo, and clinical approaches. Professor Phillips has been involved in nerve tissue engineering and regeneration research for more than 20 years. His lab pioneered Engineered Neural Tissue (EngNT) and is developing other biomaterial and small molecule therapeutics to treat nerve injury, as well as investigating the cellular, molecular, and mechanical properties of nerves.


David Hercher obtained his MSc in molecular biology from the University of Vienna and his Dr. scient. med. from the Medical University of Vienna. Since 2017, he is the head of the Neuroregeneration Group at the Ludwig Boltzmann Institute for Traumatology, where he has worked for 12 years in the field of regenerative medicine. His group focuses its research on the investigation of regenerative processes after injuries to the nervous system and the subsequent development of novel treatment options for peripheral and central nervous injuries. Furthermore, the group’s interests lie in the elucidation of modes of action of mechanical stimuli on neuronal/glial cells and tissues as well as non-viral gene therapy and novel imaging modalities and their application in the field of regenerative medicine.


Thomas Hausner was born in Salzburg, Austria, in 1965. He is Doctor of Medicine since 1993. His specializations in Medicine are General and Visceral Surgery, Trauma Surgery, and Hand- and Microsurgery. Currently he is Head of AUVA Trauma Center Vienna, Lorenz Böhler, Austria, and Co-Director of Ludwig Boltzmann Institute for Traumatology, located at Trauma Center Lorenz Böhler. Postdoctoral Lecture Qualification for Trauma Surgery at Paracelsus Medical University Salzburg in 2015. His main field of research is regeneration of peripheral nerves after trauma. This includes effects of extracorporeal shock wave therapy on nerve regeneration, bridging nerve defects and neural plasticity after injury to the peripheral nerval system.Especially bridgingnerve defects is a tissue engineering topic, e.g., the development of nerve scaffolds and tubes from silk or different other materials. Furthermore, together with his fellows he is working on various aspects of hand trauma like scaphoid fractures and their delayed healing as well as distal radius fractures. A new field for the research group is the use artificial intelligence through deep learning systems in radiodiagnostic of fractures. Dr. Hausner is also member of the German Nerve Club, an interdisciplinary nerve study group.

Bibliographic Information

Buy it now

Buying options

eBook USD 379.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access