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Advancements of Mass Spectrometry in Biomedical Research

  • Covers therapeutic fields utilizing mass spectrometry and proteomic discovery, including the newest field, lipodomics
  • Discusses the most recent proteomic methodology as well as innovative approaches to protein separation that increase the power of this technique
  • Provides new insights into hnological and pharmaceutical applications of mass spectrometry
  • Describes how researchers unfamiliar with mass spectrometry may partner with proteomic scientists most optimally to enhance their own work

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1140)

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Table of contents (47 chapters)

  1. Front Matter

    Pages i-xxi
  2. Mass Spectrometry for Proteomics-Based Investigation

    • Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha et al.
    Pages 1-26
  3. Mass Spectrometry-Based Tissue Imaging of Small Molecules

    • Carly N. Ferguson, Joseph W. M. Fowler, Jonathan F. Waxer, Richard A. Gatti, Joseph A. Loo
    Pages 99-109
  4. Proteomics and Non-proteomics Approaches to Study Stable and Transient Protein-Protein Interactions

    • Armand G. Ngounou Wetie, Izabela Sokolowska, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha, Alisa G. Woods et al.
    Pages 121-142
  5. Contribution of Mass Spectrometry-Based Proteomics to Discoveries in Developmental Biology

    • Yutaka Hashimoto, Todd M. Greco, Ileana M. Cristea
    Pages 143-154
  6. Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry

    • Cristian V. A. Munteanu, Gabriela N. ChiriÅ£oiu, Andrei-Jose Petrescu, Ștefana M. Petrescu
    Pages 155-167
  7. Identification of Posttranslational Modifications (PTMs) of Proteins by Mass Spectrometry

    • Roshanak Aslebagh, Kelly L. Wormwood, Devika Channaveerappa, Armand G. Ngounou Wetie, Alisa G. Woods, Costel C. Darie
    Pages 199-224
  8. Selective Derivatization of Hexahistidine-Tagged Recombinant Proteins

    • Vasantha Krishna Kadambar, Artem Melman
    Pages 237-250
  9. Investigation of Antibody-Drug Conjugates by Mass Spectrometry

    • Madhuri Jayathirtha, Costel C. Darie
    Pages 251-263
  10. Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides

    • Marius Mihăşan, Kelly L. Wormwood, Izabela Sokolowska, Urmi Roy, Alisa G. Woods, Costel C. Darie
    Pages 265-287
  11. Strategies for Membrane Protein Analysis by Mass Spectrometry

    • Rafael C. Prados-Rosales, Guillermo Aragoneses-Cazorla, Hector Estevez, Estefania Garcia-Calvo, Andres Machuca, Jose L. Luque-Garcia
    Pages 289-298
  12. The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses

    • Kelly L. Wormwood, Liulin Deng, Ahmed M. Hamid, Daniel DeBord, Laura Maxon
    Pages 299-316
  13. Application of Ion Mobility Mass Spectrometry in Lipidomics

    • Fereshteh Zandkarimi, Lewis M. Brown
    Pages 317-326
  14. Mass Spectrometry in Advancement of Redox Precision Medicine

    • Xiaofei Chen, Jingyun Lee, Hanzhi Wu, Allen W. Tsang, Cristina M. Furdui
    Pages 327-358

About this book

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered.  Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.

Editors and Affiliations

  • Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, USA

    Alisa G. Woods, Costel C. Darie

About the editors

Dr. Costel C. Darie started his biomedical career as a nurse at the Murgeni Hospital, Romania. He received his BS and MS in biochemistry at the Alexandru Ioan Cuza University from Iasi, Romania, and performed research under Dr. Vlad Artenie. He continued his Ph.D. studies with Dr. Wolfgang Haehnel at the Albert-Ludwigs Universitaet, Freiburg, Germany, after which he worked in the labs of Drs. Paul M. Wassarman & Micsunica Platica (Mount Sinai School of Medicine) and Thomas A. Neubert (New York University Medical Center). He currently is an Associate Professor of Chemistry and Biomolecular Science at Clarkson University, where he is the lead of the Biochemistry and Proteomics Group.

 

Dr. Alisa Woods received her BS in psychology from the State University of New York (SUNY) at Plattsburgh and her PhD in biology from the University of California, Irvine, with Dr. Christine Gall. She continued with post-doctoral training at the University of Freiburg, Germany, with Dr. Michael Frotscher and completed a Master's degree in Mental Health Counseling at the University of Massachusetts, Boston. She is currently a Research Associate Professor of Chemistry and Biomolecular Science at Clarkson University, where she works in the Laboratory for Biochemistry and Proteomics.

Bibliographic Information

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access