Prolactin Disorders

1. Front Matter

   Pages i-xiii

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2. History of Prolactin Disorders

   • John AH Wass

   Pages 1-10

3. Pituitary Anatomy and Development

   • Ronald M. Lechan, Knarik Arkun, Roberto Toni

   Pages 11-53

4. Prolactin Assays and Regulation of Secretion: Animal and Human Data

   • Nadine Binart, Jacques Young, Philippe Chanson

   Pages 55-78

5. Physiological Actions and Receptors

   • Nelson D. Horseman

   Pages 79-93

6. Prolactin Excess and Deficiency: Epidemiology, Causes (Excluding Prolactin-Secreting Pituitary Tumors)

   • Rocío Villar Taibo, Mildred Sifontes Dubon, Ignacio Bernabeu Morón, Felipe F. Casanueva

   Pages 95-110

7. Prolactin-Secreting Pituitary Adenomas: Epidemiology and Natural History

   • Lisa L. Morselli, Janet A. Schlechte

   Pages 111-126

8. Prolactin-Secreting Pituitary Adenomas: Pathology, Clinical Manifestations, and Diagnosis

   • Andrea Glezer, Marcello D. Bronstein

   Pages 127-136

9. Prolactin-Secreting Pituitary Adenomas: Clinical Management

   • Alexander Faje, Marcus A. Zachariah, Brooke Swearingen

   Pages 137-159

10. Prolactin and Pregnancy

    • Mark E. Molitch

    Pages 161-174

11. Prolactinomas in Children and Adolescents

    • Takara L. Stanley, Madhusmita Misra

    Pages 175-187

12. Prolactinomas in Men

    • Dominique Maiter

    Pages 189-204

13. Plurihormonal Adenomas

    • Artak Labadzhyan, Shlomo Melmed

    Pages 205-217

14. Aggressive Prolactin-Secreting Pituitary Adenomas and Carcinomas

    • Dongyun Zhang, Anthony P. Heaney

    Pages 219-236

15. Back Matter

    Pages 237-242

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This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas. Timely and up-to-date, it opens with a review of the historical aspects of prolactin research and a discussion of pituitary anatomy and physiology. Several chapters examine basic and translational aspects of prolactin physiology, focusing on recent developments and future directions. The main portion of the book is comprised of chapters presenting the clinical aspects of prolactin excess or deficiency, with particular emphasis placed on prolactin-secreting pituitary adenomas and co-secreting tumors. Concluding chapters address prolactin-secreting pituitary adenomas in special populations – women in the preconception period or during pregnancy, children and adolescents, and men – as well as plurihormonal and aggressive adenomas and carcinomas.


Written and edited by experts in the field, Prolactin Disorders will be a ready reference for a diverse array of professionals, from basic scientists to clinical investigators and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology and neuro-oncology.

• Benign neoplasm
• Galactorrhea
• Hyperprolactinemia
• Hypoprolactinemia
• Lactation
• Luteotropin
• Macroadenoma
• Microadenoma
• Pituitary adenoma
• Pituitary gland
• Plurihormonal adenoma
• Prolactin
• Prolactinoma
• Transsphenoidal surgery
• metabolic disease

• Neuroendocrine and Pituitary Clinical Center, Massachusetts General Hospital, Boston, USA

  Nicholas A. Tritos, Anne Klibanski

Nicholas A. Tritos, MD, DSc, Associate Professor of Medicine, Harvard Medical School, Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA


Anne Klibanski, MD, Laurie Carrol Guthart Professor of Medicine, Harvard Medical School, Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA

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