Authors:
- Comprehensive overview of a new group of human progenitor stem cells
- Highlights that these newly detected stem cells represent a specific developmental step which is found only in humans.
- Detailed description of the development and formation of the different types of stem cells
Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 230)
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Table of contents (1 chapter)
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Front Matter
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Back Matter
About this book
This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs.
The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets.
These newly detected stem cells represent a specific developmental step which is found only in humans.
Reviews
“This expert‐level book is most appropriate for developmental biologists with an understanding of embryology and histology. … The book includes numerous light‐ and electron‐microscope images that complement the main points. … This monograph offers a unique hypothesis on the origin and migration of a newly identified source of fetal stem cells.” (Erin Rae Leslie, Doody's Book Reviews, June 07, 2019)
Authors and Affiliations
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Department of Anatomy and Cell Biology, Institute of Anatomy, University of Bonn, Bonn, Germany
Hubert Wartenberg
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Department of Neuroanatomy, Institute of Anatomy, University of Bonn, Bonn, Germany
Andreas Miething
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Department of Cellular and Molecular Medicine, University of Copenhagen, København N, Denmark
Kjeld Møllgård
Bibliographic Information
Book Title: The Origin of a New Progenitor Stem Cell Group in Human Development
Book Subtitle: An Immunohistochemical-, Light- and Electronmicroscopical Analysis
Authors: Hubert Wartenberg, Andreas Miething, Kjeld Møllgård
Series Title: Advances in Anatomy, Embryology and Cell Biology
DOI: https://doi.org/10.1007/978-3-030-02050-7
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2019
Softcover ISBN: 978-3-030-02049-1Published: 22 January 2019
eBook ISBN: 978-3-030-02050-7Published: 12 December 2018
Series ISSN: 0301-5556
Series E-ISSN: 2192-7065
Edition Number: 1
Number of Pages: XII, 79
Number of Illustrations: 76 b/w illustrations, 2 illustrations in colour
Topics: Cell Biology, Neurosciences, Anatomy