Progress in the Chemistry of Organic Natural Products 108

1. Front Matter

   Pages i-v

   PDF

2. Chemistry and Biology of Selected Mexican Medicinal Plants

   • Rachel Mata, Mario Figueroa, Andrés Navarrete, Isabel Rivero-Cruz

   Pages 1-142

3. Biomolecular Targets of Oxyprenylated Phenylpropanoids and Polyketides

   • Serena Fiorito, Francesco Epifano, Francesca Preziuso, Vito Alessandro Taddeo, Salvatore Genovese

   Pages 143-205

4. Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities

   • Darlon Irineu Bernardi, Fernanda Oliveira das Chagas, Afif Felix Monteiro, Gabriel Franco dos Santos, Roberto Gomes de Souza Berlinck

   Pages 207-296

The first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. The second contribution provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses. And the third contribution discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.

• endophytic actinobacteria
• polyketide total synthesis
• alkaloid total synthesis
• Apiaceae
• biological targets
• Coumarins
• antidiabetic plants
• chemical diversity
• analgesic and anti-inflammatory agents

• College of Pharmacy, The Ohio State University, Columbus, USA

  A. Douglas Kinghorn

• Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

  Heinz Falk

• UCL School of Pharmacy, University College London, Research, London, UK

  Simon Gibbons

• Grad. School of Pharmaceutical Science, Hokkaido University, Fukuoka, Japan

  Jun'ichi Kobayashi

• Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

  Yoshinori Asakawa

• School of Pharmaceutical Sciences, South-Central Univ. for Nationalities, Wuhan, China

  Ji-Kai Liu

Policies and ethics