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Genetic Epidemiology

Methods and Protocols

  • Book
  • © 2018

Overview

Editors:
  1. Evangelos Evangelou

    1. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1793)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction to Epidemiological Studies

    • Lazaros Belbasis, Vanesa Bellou
    Pages 1-6

  3. Key Concepts in Genetic Epidemiology

    • Kalliope Panoutsopoulou, Eleanor Wheeler
    Pages 7-24

  4. Quality Control of Common and Rare Variants

    • Kalliope Panoutsopoulou, Klaudia Walter
    Pages 25-36

  5. Genome-Wide Association Studies

    • Abbas Dehghan
    Pages 37-49

  6. Assessing Rare Variation in Complex Traits

    • Karoline Kuchenbaecker, Emil Vincent Rosenbaum Appel
    Pages 51-71

  7. Meta-Analysis of Common and Rare Variants

    • Kyriaki Michailidou
    Pages 73-88

  8. Gene-Gene and Gene-Environment Interactions

    • Andrew T. DeWan
    Pages 89-110

  9. Genetic Association in the HLA Region

    • Loukas Moutsianas, Javier Gutierrez-Achury
    Pages 111-134

  10. Novel Methods for Family-Based Genetic Studies

    • Qi Yan
    Pages 135-144

  11. Methods for Polygenic Traits

    • Raha Pazoki
    Pages 145-156

  12. Multivariate Methods for Meta-Analysis of Genetic Association Studies

    • Niki L. Dimou, Katerina G. Pantavou, Georgia G. Braliou, Pantelis G. Bagos
    Pages 157-182

  13. Methods of Analysis and Meta-Analysis for Identifying Differentially Expressed Genes

    • Panagiota I Kontou, Athanasia Pavlopoulou, Pantelis G. Bagos
    Pages 183-210

  14. A Primer in Mendelian Randomization Methodology with a Focus on Utilizing Published Summary Association Data

    • Niki L. Dimou, Konstantinos K. Tsilidis
    Pages 211-230

  15. Copy Number Variation

    • Aurélien Macé, Zoltán Kutalik, Armand Valsesia
    Pages 231-258

  16. From Identification to Function: Current Strategies to Prioritise and Follow-Up GWAS Results

    • Antonio J. Berlanga-Taylor
    Pages 259-275

  17. Translating Human Genetics into Novel Drug Targets

    • Karol Estrada, Alzheimer’s Disease Neuroimaging Initiative
    Pages 277-290

  18. Back Matter

    Pages 291-299
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Keywords

About this book

This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented.  The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.

Editors and Affiliations

  • Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece

    Evangelos Evangelou

Bibliographic Information

  • Book Title: Genetic Epidemiology

  • Book Subtitle: Methods and Protocols

  • Editors: Evangelos Evangelou

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7868-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7867-0Published: 07 June 2018

  • Softcover ISBN: 978-1-4939-9309-3Published: 25 July 2019

  • eBook ISBN: 978-1-4939-7868-7Published: 06 June 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 299

  • Number of Illustrations: 12 b/w illustrations, 23 illustrations in colour

  • Topics: Human Genetics

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