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Methods in Molecular Biology

ATM Kinase

Methods and Protocols

Editors: Kozlov, Sergei V. (Ed.)

  • Includes cutting-edge methods and protocols for the study of ataxia-telangiectasia research
    Provides step-by-step detail essential for reproducible results
    Contains key notes and implementation advice from the experts

Buy this book

eBook 91,62 €
price for Spain (gross)
  • ISBN 978-1-4939-6955-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 114,39 €
price for Spain (gross)
  • ISBN 978-1-4939-6953-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Ataxia–telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and cancer predisposition. This detailed volume explores the ever expanding field of research into the ATM (ataxia-telangiectasia, mutated) gene and the role played by ATM kinase in DNA damage signaling and diverse cellular processes. What follows is a handy desktop reference for both seasoned A-T researchers and postgraduate students, as it demonstrates the breadth of recent developments in A-T studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Both classic and cutting-edge techniques are described, including ATM gene mutation detection, assays for radiosensitivity and radioresistant DNA synthesis, new methods to measure ATM kinase activity by imaging microscopy and high content screening as well as proteomics, phosphoproteomics and bioinformatics approaches to decipher ATM-dependent signalling pathways. Additional methods include generation of patient-specific stem cells and approaches to study ATM functions in the nervous system. 
Comprehensive and practical, ATM Kinase: Methods and Protocols aims to ignite and attract the interest of colleagues from diverse fields to A-T research in an effort to bring their expertise and fresh ideas to resolve many A-T puzzles still waiting to be pieced together and to alleviate the suffering of A-T children and their families.

Table of contents (30 chapters)

  • Assaying Radiosensitivity of Ataxia-Telangiectasia

    Hu, Hailiang (et al.)

    Pages 1-11

    Preview Buy Chapter 48,34 €
  • Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique

    Kijas, Amanda W. (et al.)

    Pages 13-23

    Preview Buy Chapter 48,34 €
  • ATM Gene Mutation Detection Techniques and Functional Analysis

    Rieunier, Guillaume (et al.)

    Pages 25-42

    Preview Buy Chapter 48,34 €
  • An HTRF® Assay for the Protein Kinase ATM

    Adams, Phillip (et al.)

    Pages 43-56

    Preview Buy Chapter 48,34 €
  • ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform

    Bardelle, Catherine (et al.)

    Pages 57-70

    Preview Buy Chapter 48,34 €

Buy this book

eBook 91,62 €
price for Spain (gross)
  • ISBN 978-1-4939-6955-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 114,39 €
price for Spain (gross)
  • ISBN 978-1-4939-6953-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
ATM Kinase
Book Subtitle
Methods and Protocols
Editors
  • Sergei V. Kozlov
Series Title
Methods in Molecular Biology
Series Volume
1599
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media LLC
eBook ISBN
978-1-4939-6955-5
DOI
10.1007/978-1-4939-6955-5
Hardcover ISBN
978-1-4939-6953-1
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 437
Number of Illustrations and Tables
24 b/w illustrations, 69 illustrations in colour
Topics