Overview
Examines the techniques used to measure percutaneous penetration of drugs and chemicals that have found application in assessment of bioavailability and bioequivalence
Discusses advances in drug delivery and how they have been used in clinical and scientific investigations
Brings the most current knowledge in this area to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds
Includes supplementary material: sn.pub/extras
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (23 chapters)
-
Front Matter
-
Percutaneous Absorption
-
Front Matter
-
-
In Vitro Drug Release
-
Front Matter
-
-
Bioequivalence of Topical Drug Products
-
Front Matter
-
-
Bioequivalence: Targeted Drug Delivery
-
Front Matter
-
-
Transdermal Drugs and Modelling
-
Front Matter
-
Keywords
About this book
This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs.
 The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.
Editors and Affiliations
About the editors
Vinod P. Shah is a pharmaceutical consultant. He was Scientific Secretary of International Pharmaceutical Federation (FIP) and is now Chair of Regulatory Sciences Special Interest Group of FIP. Dr. Shah has served at the U.S. Food and Drug Administration and has developed several regulatory guidances for the pharmaceutical industry in biopharmaceutics and topical drug products. Dr. Shah is a fellow of FIP as well as the American Association of Pharmaceutical Scientists (AAPS), where he served as president for a year. He is a recipient of an honorary doctorate from Semmelweis University, Budapest, Hungary. Â
Howard I. Maibach is professor of dermatology at the University of California, San Francisco. He received his M.D. at Tulane University Medical School in New Orleans, Louisiana, and completed his residency and research fellowships at the University of Pennsylvania in Philadelphia, Pennsylvania. Professor Maibach is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted research and written extensively. Prof. Maibach has served on the editorial boards of more than thirty scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health.
John Jenner is a principal scientist at The Defence Science and Technology Laboratory in the UK. He has a degree in pharmacology from the University of Manchester in Manchester, UK, and a Ph.D. from the University of Surrey, Guildford, UK. John has spent his career studying defense against and treatment of highly toxic chemicals. He has an enduring research interest in percutaneously active chemicals, whether toxic materials or drugs, and experience in the design and testing of transdermal formulations. His current interests include the translation of in vitro penetration measurements to in vivo using mathematical modelling.
Bibliographic Information
Book Title: Topical Drug Bioavailability, Bioequivalence, and Penetration
Editors: Vinod P. Shah, Howard I. Maibach, John Jenner
DOI: https://doi.org/10.1007/978-1-4939-1289-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4939-1288-9Published: 30 January 2015
Softcover ISBN: 978-1-4939-3856-8Published: 05 October 2016
eBook ISBN: 978-1-4939-1289-6Published: 30 January 2015
Edition Number: 2
Number of Pages: XIII, 402
Number of Illustrations: 48 b/w illustrations, 16 illustrations in colour
Topics: Pharmacology/Toxicology, Animal Physiology, Biological and Medical Physics, Biophysics