Overview
- First book in the Interactomics and Systems Biology book series?
- Provides a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones
- Discusses their role in cell stress responses and in diseases from a global network perspective
- Includes supplementary material: sn.pub/extras
Part of the book series: Interactomics and Systems Biology (INTERACTOM, volume 1)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (17 chapters)
-
Front Matter
-
A Global View of the Chaperone Network
-
Front Matter
-
-
Chaperones at the Ribosome
-
Front Matter
-
-
The Hsp70 and Hsp40 Chaperone Networks
-
Front Matter
-
-
The Hsp90 Chaperone Network
-
Front Matter
-
-
The p23 Chaperone Network
-
Front Matter
-
-
The Ubiquitin-Proteasome System Network
-
Front Matter
-
Keywords
About this book
Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion.
In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases.
This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​
Reviews
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: The Molecular Chaperones Interaction Networks in Protein Folding and Degradation
Editors: Walid A. Houry
Series Title: Interactomics and Systems Biology
DOI: https://doi.org/10.1007/978-1-4939-1130-1
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4939-1129-5Published: 02 September 2014
Softcover ISBN: 978-1-4939-4864-2Published: 10 September 2016
eBook ISBN: 978-1-4939-1130-1Published: 01 September 2014
Edition Number: 1
Number of Pages: XV, 485
Number of Illustrations: 8 b/w illustrations, 54 illustrations in colour
Topics: Systems Biology, Protein Science, Biomedicine general