Editors:
- Detailed overview of the wide range of nuclear envelope functions that can and do impact cancer
- Timely volume that addresses a re-emerging hot topic, juxtaposing some of the historical and contemporary usage of nuclear envelope morphology
- Each chapter includes a short introduction to each section of the book to give readers both the larger cancer perspective of different molecular studies and an overview of the contents
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 773)
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Table of contents (28 chapters)
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Front Matter
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History and Use of the Nuclear Envelope in Cancer Prognosis
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Front Matter
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The Nuclear Envelope in Cell Cycle Regulation and Signaling
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Front Matter
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Nuclear Envelope Regulation of the Genome
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Front Matter
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Functions of the NPC in Cancer
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Front Matter
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About this book
"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."
Editors and Affiliations
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University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom
Eric C. Schirmer, Jose I. de las Heras
About the editors
Bibliographic Information
Book Title: Cancer Biology and the Nuclear Envelope
Book Subtitle: Recent Advances May Elucidate Past Paradoxes
Editors: Eric C. Schirmer, Jose I. de las Heras
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4899-8032-8
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2014
Hardcover ISBN: 978-1-4899-8031-1Published: 23 February 2014
Softcover ISBN: 978-1-4939-5481-0Published: 03 September 2016
eBook ISBN: 978-1-4899-8032-8Published: 22 February 2014
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIII, 611
Number of Illustrations: 14 b/w illustrations, 84 illustrations in colour
Topics: Cancer Research, Medical Microbiology, Protein Science, Membrane Biology, Biomedicine general