Overview
- Editors:
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James N. Herron
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University of Utah, Salt Lake City, USA
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Wim Jiskoot
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National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
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Daan J. A. Crommelin
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Groningen-Utrecht Institute for Drug Exploration, Utrecht University, and Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
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Table of contents (9 chapters)
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Front Matter
Pages i-xvii
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- Wim Jiskoot, Vladimir Hlady, John J. Naleway, James N. Herron
Pages 1-63
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- Michael Bloemendal, W. Curtis Johnson Jr.
Pages 65-100
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- David G. Vander Velde, James Matsuura, Mark C. Manning
Pages 179-218
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- Kenneth P. Murphy, Ernesto Freire
Pages 219-241
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- Joost J. M. Holthuis, Reinoud J. Driebergen
Pages 243-299
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Back Matter
Pages 351-362
About this book
Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca demic environments, forcing pharmaceutical scientists to explore a domain previ ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad ministration have been examined for proteins, no real, generally applicable alter native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.
Editors and Affiliations
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University of Utah, Salt Lake City, USA
James N. Herron
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National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
Wim Jiskoot
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Groningen-Utrecht Institute for Drug Exploration, Utrecht University, and Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Daan J. A. Crommelin