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Hypoxic Pulmonary Vasoconstriction

Cellular and Molecular Mechanisms

  • Book
  • © 2004

Overview

Editors:
  1. Jason X. -J. Yuan

    1. Department of Medicine, University of California, San Diego School of Medicine, San Diego

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  • Complete reference on hypoxic pulmonary vasoconstriction and hypoxia-mediated pulmonary hypertension
  • Can be utilized by the physician-scientist and researcher in the laboratory as both a technical manual and reference
  • Designed for clinicians to guide and improve clinical treatment and diagnosis of patients with hypoxia mediated pulmonary vascular disease and right heart failure

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 252)

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Table of contents (33 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Physiology and Pathophysiology of Hypoxic Pulmonary Vasoconstriction

    1. Front Matter

      Pages 1-1
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    2. Physiological Function of Hypoxic Pulmonary Vasoconstriction

      • Charles A. Hales
      Pages 3-14

    3. Hypoxic Pulmonary Vasoconstriction: Heterogeneity

      • Christopher A. Dawson
      Pages 15-33

    4. The Physics of Hypoxic Pulmonary Hypertension and Its Connection with Gene Actions

      • Yuan-Cheng Fung, Wei Huang
      Pages 35-50

  3. Role of Intra Cellular Ca2+ and Ca2+ Sensitivity in Hypoxic Pulmonary Vasoconstriction

    1. Front Matter

      Pages 51-51
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    2. Ca2+ Sparks in Pulmonary Artery Smooth Muscle Cells: Implications for Hypoxic Pulmonary Vasoconstriction

      • Wei-Min Zhang, Carmelle V. Remillard, James S.K. Sham
      Pages 53-66

    3. Hypoxia-Mediated Regulation of Ca2+ Transients in Pulmonary Artery Smooth Muscle Cells

      • Jean-Pierre Savineau, Sébastien Bonnet, Roger Marthan
      Pages 67-79

    4. Calcium Mobilization by Hypoxia in Pulmonary Artery Smooth Muscle

      • A. Mark Evans, Michelle Dipp
      Pages 81-101

    5. Critical Role of Ca+ Sensitization in Acute Hypoxic Pulmonary Vasoconstriction

      • Tom P. Robertson, Ivan F. McMurtry
      Pages 103-117

  4. Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction

    1. Front Matter

      Pages 119-119
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    2. Regulation of Ion Channels in Pulmonary Artery Smooth Muscle Cells

      • Sergey V. Smirnov
      Pages 121-134

    3. Regulation of O2-Sensitive K+ Channels by a Mitochondrial Redox Sensor: Implications for Hypoxic Pulmonary Vasoconstriction

      • Rohit Moudgil, Evangelos D. Michelakis, Stephen L. Archer
      Pages 135-164

    4. Hypoxic Regulation of K+ Channel Expression and Function in Pulmonary Artery Smooth Muscle Cells

      • Hemal H. Patel, Carmelle V. Remillard, Jason X. -J. Yuan
      Pages 165-197

    5. Transient Receptor Potential Channels and Capacitative Ca2+ Entry in Hypoxic Pulmonary Vasoconstriction

      • Alison M. Gurney, Lih-Chyuan Ng
      Pages 199-214

  5. Role of Endothelium in Hypoxic Pulmonary Vasoconstriction

    1. Front Matter

      Pages 215-215
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    2. Endothelium-dependent Hypoxic Pulmonary Vasoconstriction

      • Jeremy P. T. Ward, Philip I. Aaronson
      Pages 217-230

  6. Mechanisms of Oxygen Sensing in the Pulmonary Vasculature

    1. Front Matter

      Pages 231-231
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    2. Chemistry of Oxygen and Its Derivatives in the Lung

      • Lisa A. Palmer
      Pages 233-245

    3. Interaction of Oxidants With Pulmonary Vascular Signaling Systems

      • Sachin A. Gupte, Michael S. Wolin
      Pages 247-262
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Editors and Affiliations

  • Department of Medicine, University of California, San Diego School of Medicine, San Diego

    Jason X. -J. Yuan

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