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Formulation, Characterization, and Stability of Protein Drugs

Case Histories

  • Book
  • © 2002

Overview

Editors:
  1. Rodney Pearlman

    1. Megabios Corporation, Burlingame, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Y. John Wang

    1. Scios Nova, Inc., Mountain View, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Pharmaceutical Biotechnology (PBIO, volume 9)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xxviii
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  2. A Compendium and Hydropathy/ Flexibility Analysis of Common Reactive Sites in Proteins: Reactivity at Asn, Asp, Gin, and Met Motifs in Neutral pH Solution

    • Michael F. Powell, Godfrey Amphlett, Jerry Cacia, William Callahan, Eleanor Cannova-Davis, Byeong Chang et al.
    Pages 1-140

  3. Characterization, Stability, and Formulations of Basic Fibroblast Growth Factor

    • Y. John Wang, Zahra Shahrokh, Sriram Vemuri, Gert Eberlein, Irina Beylin, Mark Busch
    Pages 141-180

  4. The Characterization, Stabilization, and Formulation of Acidic Fibroblast Growth Factor

    • David B. Volkin, C. Russell Middaugh
    Pages 181-217

  5. Stability, Characterization, Formulation, and Delivery System Development for Transforming Growth Factor-Beta1

    • Wayne R. Gombotz, Susan C. Pankey, Lisa S. Bouchard, Duke H. Phan, Alan P. MacKenzie
    Pages 219-245

  6. Stability and Characterization of Recombinant Human Relaxin

    • Tue H. Nguyen, Steven J. Shire
    Pages 247-274

  7. Interferon-β-1b (Betaseron®): A Model for Hydrophobic Therapeutic Proteins

    • Leo S. Lin, Michael G. Kunitani, Maninder S. Hora
    Pages 275-301

  8. Characterization, Formulation, and Stability of Neupogen® (Filgrastim), a Recombinant Human Granulocyte-Colony Stimulating Factor

    • Alan C. Herman, Thomas C. Boone, Hsieng S. Lu
    Pages 303-328

  9. Development and Shelf-Life Determination of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (LEUKINE®, GM-CSF)

    • John Geigert, Barbara F. D. Ghrist
    Pages 329-342

  10. Formulation Development of an Antifibrin Monoclonal Antibody Radiopharmaceutical

    • Madhav S. Kamat, Glen L. Tolman, John M. Brown
    Pages 343-364

  11. Biophysical Characterization and Formulation of TP40: A Chimeric Protein that Requires a pH-Dependent Conformational Change for Its Biological Activity

    • Gautam Sanyal, Dorothy Marquis-Omer, C. Russell Middaugh
    Pages 365-392

  12. Stability Characterization and Formulation Development of Recombinant Human Deoxyribonuclease I [Pulmozyme®, (Dornase Alpha)]

    • Steven J. Shire
    Pages 393-426

  13. Back Matter

    Pages 427-432
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Keywords

About this book

Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.

Editors and Affiliations

  • Megabios Corporation, Burlingame, USA

    Rodney Pearlman

  • Scios Nova, Inc., Mountain View, USA

    Y. John Wang

Bibliographic Information

  • Book Title: Formulation, Characterization, and Stability of Protein Drugs

  • Book Subtitle: Case Histories

  • Editors: Rodney Pearlman, Y. John Wang

  • Series Title: Pharmaceutical Biotechnology

  • DOI: https://doi.org/10.1007/b112935

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-306-45332-8Published: 31 October 1996

  • Softcover ISBN: 978-1-4757-7047-6Published: 06 May 2013

  • eBook ISBN: 978-0-306-47452-1Published: 11 April 2006

  • Series ISSN: 1078-0467

  • Edition Number: 1

  • Number of Pages: XXVIII, 432

  • Topics: Pharmacology/Toxicology, Pharmacy

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