Overview
- Editors:
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Scott K. Durum
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National Cancer Institute, Frederick, USA
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Kathrin Muegge
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National Cancer Institute, Frederick, USA
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Table of contents (24 chapters)
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- Thomas Hünig, Anneliese Schimpl
Pages 1-19
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- Ursula von Freeden-Jeffry, Thomas A. Moore, Albert Zlotnik, Richard Murray
Pages 21-36
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- Jacques J. Peschon, Brian C. Gliniak, Philip Morrissey, Eugene Maraskovsky
Pages 37-52
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- Charles R. Maliszewski, Mary K. Kennedy, Kim A. Campbell
Pages 53-67
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- Hans-Pietro Eugster, Matthias Müller, Michel Le Hir, Bernhard Ryffel
Pages 103-118
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- Giamila Fantuzzi, Charles A. Dinarello
Pages 129-153
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- Philip J. Morrissey, Moira Glaccum, Charles R. Maliszewski, Jacques Peschon
Pages 155-171
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- Keisuke Kuida, Judith A. Lippke, Michael S.-S. Su, Richard A. Flavell
Pages 173-188
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- Mark W. Moore, Grace Cacalano
Pages 189-205
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- Jan Vilček, Michel Aguet, Luiz F. L. Reis
Pages 207-225
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- Alistair J. Ramsay, Manfred Kopf
Pages 227-236
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- Kanji Yoshida, Tetsuya Taga, Mikiyoshi Saito, Atsushi Kumanogoh, Takashi Tanaka, Keiichi Ozono et al.
Pages 259-285
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- Shizuo Akira, Takashi Tanaka, Tadamitsu Kishimoto
Pages 287-313
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- Carol B. Ware, Joan S. Hunt
Pages 315-334
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- Suhas Kallapur, Marcia Shull, Thomas Doetschman
Pages 335-368
About this book
My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al though the latter finding is of course a wonderful incentive for fur ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.
Reviews
...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne
". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal
