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Therapeutic Interventions in the Complement System

  • Book
  • © 2000

Overview

Editors:
  1. John D. Lambris

    1. University of Pennsylvania School of Medicine, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. V. Michael Holers

    1. University of Colorado Health Sciences Center, Denver, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Immunology (CONTIM)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Complement as a Regulatory and Effector Pathway in Human Diseases

    • V. Michael Holers
    Pages 1-32

  3. The Regulation of C1 Activation and Its Role in Disease

    • C. Erik Hack
    Pages 33-56

  4. Inhibition of Complement Serine Proteases as a Therapeutic Strategy

    • Sthanam V. L. Narayana, Y. Sudhakara Babu, John E. Volanakis
    Pages 57-74

  5. Complement Inhibitors Targeting C3, C4, and C5

    • Arvind Sahu, Dimitrios Morikis, John D. Lambris
    Pages 75-112

  6. Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation

    • Rick A. Wetsel, Jens Kildsgaard, David L. Haviland
    Pages 113-153

  7. Modulation of Disease Using Recombinant Human Endogenous Complement Inhibitors

    • Richard J. Quigg
    Pages 155-170

  8. Roles of Integrins CR3 and CR4 in Disease and Therapeutic Strategies

    • Yu Xia, Gordon D. Ross
    Pages 171-204

  9. Inhibition of Complement in the Membrane Attack Pathway

    • B. Paul Morgan
    Pages 205-224

  10. Evaluation of Complement Inhibitors

    • Patricia C. Giclas
    Pages 225-236

  11. Use of Animal Models to Define Complement Functions

    • Peter A. Ward, Boris J. Czermak, Markus Huber-Lang, Katherine Diehl, Hans P. Friedl
    Pages 237-253

  12. Back Matter

    Pages 255-259
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Keywords

About this book

A team of expert investigators and clinical researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, spelling out the activation pathways and complement receptors. Informative animal models are discussed in detail, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. The emphasis throughout is on the pros and cons of the therapeutic use of recombinant complement inhibitors in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for today's researcher and biotechnologist effective strategies of drug discovery and development that are producing valuable new complement inhibitors for the treatment of a wide variety of clinically important diseases.

Editors and Affiliations

  • University of Pennsylvania School of Medicine, Philadelphia, USA

    John D. Lambris

  • University of Colorado Health Sciences Center, Denver, USA

    V. Michael Holers

Bibliographic Information

  • Book Title: Therapeutic Interventions in the Complement System

  • Editors: John D. Lambris, V. Michael Holers

  • Series Title: Contemporary Immunology

  • DOI: https://doi.org/10.1007/978-1-59259-017-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-89603-587-4Published: 15 April 2000

  • Softcover ISBN: 978-1-4684-9612-3Published: 08 August 2012

  • eBook ISBN: 978-1-59259-017-9Published: 15 April 2000

  • Edition Number: 1

  • Number of Pages: X, 260

  • Topics: Immunology, Pharmaceutical Sciences/Technology, Quality of Life Research

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