Immune Complexes and Human Cancer

1. Front Matter

   Pages i-xv

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2. Clinical Significance and Nature of Circulating Immune Complexes in Melanoma Patients

   • Rishab K. Gupta, Donald L. Morton

   Pages 1-53

3. Clinical Relevance of Immune Complexes, Associated Antigen, and Antibody in Cancer

   • Fernando A. Salinas, Kian H. Wee, Hulbert K. Silver

   Pages 55-109

4. The Pathophysiology of Circulating Immune Complexes: Their Role in Host-Tumor Interactions and Removal by Immunoadsorption Therapy

   • Terence M. Phillips, Thomas V. Holohan, Stefan Korac, Newton S. More, William D. Queen

   Pages 111-137

5. Immune Complexes in Patients Bearing Solid Tumors

   • Didier Cupissol, Christian Thierry, Bernard C. Serrou

   Pages 139-146

6. Immunosuppressor Control as a Modality of Cancer Treatment: Effect of Plasma Adsorption with Staphylococcus aureus Protein A

   • Prasanta K. Ray

   Pages 147-211

7. Blocking (Suppressor) Factors, Immune Complexes, and Extracorporeal Immunoadsorption in Tumor Immunity

   • Karl Erik Hellström, Ingegerd Hellström, Harry W. Snyder Jr., Joe P. Balint, Frank R. Jones

   Pages 213-238

8. Trials of Staphylococcal Protein A-Treated Plasma Infusions in Cancer Therapy: Clinical Effects and Implications for Mode of Action

   • F. Roy MacKintosh, Kim Bennett, Stephen W. Hall

   Pages 239-256

9. Protein A Immunoadsorption/Immunoactivation: A Critical Review

   • Mehmet F. Fer, Robert K. Oldham

   Pages 257-276

10. Back Matter

    Pages 277-280

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Immune Complexes and Human Cancer, the fifteenth volume of Contem­ porary Topics in Immunobiology, is a compilation of information derived from recent studies on the role of circulating immune complexes (CIC) in the patho­ genic manifestations of a variety of human cancers. Technical improvements in the detection of CIC in body fluids have resulted in data that indicate that CIC do occur in different types of cancer. In addition, tumor-associated antigens and antibodies have been detected in immune complexes of cancer patients' sera. Until recently the exact role and clinical relevance of immune complexes have been the subject of debate, partially because of the problems encountered in measuring immune complexes. But these problems are being confronted as more accurate measurement protocols are developed. Technical refinements, along with strict protocols, have provided evidence of heterogeneity in CIC, a factor that makes accurate detection of immune complexes in cancer patients difficult. Recent insights indicate that the measurement of immune complexes in cancer patients may be clinically useful not only as a tumor marker, but also in regard to the deranged immune response of tumor-bearing hosts and other disorders such as nephrotic syndrome, immune anemias, and clotting dysfunction.

• anemia
• antibody
• antigen
• cancer
• immune response
• immunobiology
• tumor

• Cancer Control Agency of British Columbia, Vancouver, Canada

  Fernando A. Salinas

• University of British Columbia, Vancouver, Canada

  Fernando A. Salinas

• Litton Institute of Applied Biotechnology, Rockville, USA

  Michael G. Hanna

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