Overview
- Editors:
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Michael G. Hanna
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Basic Research Program, NCI Frederick Cancer Research Center, Frederick, USA
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Fred Rapp
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Department of Microbiology and Specialized Cancer Research Center The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, USA
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Table of contents (10 chapters)
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Front Matter
Pages i-xiii
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- Satvir S. Tevethia, Fred Rapp
Pages 1-69
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- Stuart A. Aaronson, John R. Stephenson
Pages 107-126
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- Werner Schäfer, Dani P. Bolognesi
Pages 127-167
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- James N. Ihle, M. G. Hanna Jr.
Pages 169-194
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- Bert C. Del Villano, Stephen J. Kennel, Richard A. Lerner
Pages 195-207
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- Martin S. Hirsch, Max R. Proffitt, Paul H. Black
Pages 209-227
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- P. Bentvelzen, P. C. Creemers
Pages 229-238
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Back Matter
Pages 287-289
About this book
It has long been suspected, and recently confirmed, that there is an etiologic relationship between several viruses and naturally occurring neoplasias. Virus precursors in the form of nucleic acids or antigens have consistently been associated with certain neoplasias. However, the role of these virus-specified precursors in etiology remains obscure. Recent studies of virus-associated neo plasias have led to advances in molecular techniques, which have yielded increas ingly sensitive assays for detection of virus-specific nucleic acids, and which have enabled the disruption of virus particles without concomitant loss in antigenicity of the components. These procedures have, in turn, resulted in molecular probes that allow more definitive evaluation of the host response to its virus and to the tumor cell with which the virus or its precursors are associated. Evaluations of the immune response and status of the host have provided important informa tion about carcinogenesis and the tools for seroepidemiological studies of a variety of cancers. These seroepidemiological studies have demonstrated that several human cancers, e. g. , Burkitt's lymphoma and nasopharyngeal carcinoma, are probably virus-induced, and that antibodies that are diagnostic and prog nostic for these diseases are detectable. The conclusion that feline leukemia is a disease transmitted horizontally by a virus resulted primarily from immunologi cal experiments.
Editors and Affiliations
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Basic Research Program, NCI Frederick Cancer Research Center, Frederick, USA
Michael G. Hanna
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Department of Microbiology and Specialized Cancer Research Center The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, USA
Fred Rapp
