Skip to main content
SpringerLink
Log in

Biological Barriers to Protein Delivery

  • Book
  • © 1993

Overview

Editors:
  1. Kenneth L. Audus

    1. University of Kansas, Lawrence, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Thomas J. Raub

    1. The Upjohn Company, Kalamazoo, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Pharmaceutical Biotechnology (PBIO, volume 4)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xxv
    Download chapter PDF

  2. Cellular Barriers

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. The Paracellular Pathway

      • Marcelino Cereijido, Octavio Ruiz, Lorenza González-Mariscal, Rubén Gerardo Contreras, María Susana Balda, M. R. García-Villegas
      Pages 3-21

    3. Ectopeptidases

      • Nigel M. Hooper
      Pages 23-50

    4. Endosomal and Lysosomal Hydrolases

      • Sandra A. Brockman, Robert F. Murphy
      Pages 51-70

    5. Protein Uptake and Cytoplasmic Access in Animal Cells

      • Bo van Deurs, Steen H. Hansen, Sjur Olsnes, Kirsten Sandvig
      Pages 71-104

  3. Epithelial Barriers

    1. Front Matter

      Pages 105-105
      Download chapter PDF

    2. Transepithelial Transport of Proteins by Intestinal Epithelial Cells

      • Marian R. Neutra, Jean-Pierre Kraehenbuhl
      Pages 107-129

    3. Intraoral Peptide Absorption

      • Hans P. Merkle, Gregor J. M. Wolany
      Pages 131-160

    4. Macromolecular Transport across Nasal and Respiratory Epithelia

      • Larry G. Johnson, Richard C. Boucher
      Pages 161-178

    5. Dermal Absorption of Peptides and Proteins

      • Ajay K. Banga, Yie W. Chien
      Pages 179-197

    6. Rectal and Vaginal Absorption of Peptides and Proteins

      • Shozo Muranishi, Akira Yamamoto, Hiroaki Okada
      Pages 199-227

  4. Vascular Barriers

    1. Front Matter

      Pages 229-229
      Download chapter PDF

    2. Vascular Endothelial Barrier Function and Its Regulation

      • Asrar B. Malik, Alma Siflinger-Birnboim
      Pages 231-267

    3. Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers in Vivo

      • Richard D. Broadwell
      Pages 269-296

  5. Elimination Barriers

    1. Front Matter

      Pages 297-297
      Download chapter PDF

    2. Renal Uptake and Disposal of Proteins and Peptides

      • Ralph Rabkin, David C. Dahl
      Pages 299-338

    3. Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins

      • Dirk K. F. Meijer, Kornelia Ziegler
      Pages 339-408

    4. The Immune System as a Barrier to Delivery of Protein Therapeutics

      • Michael W. Konrad
      Pages 409-437

  6. Tissue Barriers

    1. Front Matter

      Pages 439-439
      Download chapter PDF
Back to top

Keywords

About this book

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

Reviews

`Of the same high quality as the earlier volumes.'
Trends in Pharmacological Sciences

Editors and Affiliations

  • University of Kansas, Lawrence, USA

    Kenneth L. Audus

  • The Upjohn Company, Kalamazoo, USA

    Thomas J. Raub

Bibliographic Information

  • Book Title: Biological Barriers to Protein Delivery

  • Editors: Kenneth L. Audus, Thomas J. Raub

  • Series Title: Pharmaceutical Biotechnology

  • DOI: https://doi.org/10.1007/978-1-4615-2898-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Hardcover ISBN: 978-0-306-44368-8Published: 30 June 1993

  • Softcover ISBN: 978-1-4613-6256-2Published: 24 October 2012

  • eBook ISBN: 978-1-4615-2898-2Published: 06 December 2012

  • Series ISSN: 1078-0467

  • Edition Number: 1

  • Number of Pages: XXV, 495

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Pharmacy

Publish with us

Policies and ethics

Back to top

Search

Navigation