Molecular Aspects of Botulinum Neurotoxin

1. Front Matter

   Pages i-xii

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2. Overview and History of Botulinum Neurotoxin Research

   • Keith A. Foster

   Pages 1-7

3. Pharmacology of Botulinum Neurotoxins: Exploitation of Their Multifunctional Activities as Transmitter Release Inhibitors and Neuron-Targeted Delivery Vehicles

   • J. O. Dolly, V. B. O’Leary, G. W. Lawrence, S. V. Ovsepian

   Pages 9-33

4. Absorption and Transport of Botulinum Neurotoxins

   • Michel R. Popoff, Chloé Connan

   Pages 35-68

5. The Botulinum Neurotoxin Complex and the Role of Ancillary Proteins

   • Bal Ram Singh, Tzuu-Wang Chang, Roshan Kukreja, Shuowei Cai

   Pages 69-101

6. Neurotoxin Structure

   • Subramanyam Swaminathan

   Pages 103-127

7. The Dual-Receptor Recognition of Botulinum Neurotoxins

   • Andreas Rummel

   Pages 129-150

8. Translocation, Entry into the Cell

   • Matthew Beard

   Pages 151-170

9. Protease Activity of the Botulinum Neurotoxins

   • Sheng Chen, Joseph T. Barbieri

   Pages 171-189

10. Molecular Basis for Persistence of Botulinum Neurotoxin: The Role of Intracellular Protein Degradation Pathways

    • Yien Che Tsai, Brian E. Moller, Michael Adler, George A. Oyler

    Pages 191-205

11. Clostridium botulinum Genomes and Genetic Diversity

    • Theresa J. Smith

    Pages 207-228

12. Botulinum Neurotoxin Risks and Detection in Environment, Agriculture and Food Chains

    • Miia Lindström, Riikka Keto-Timonen, Hannu Korkeala

    Pages 229-258

13. Botulism as a Disease of Humans

    • Susan E. Maslanka

    Pages 259-289

14. Prevention and Treatment of Botulism

    • Michael Adler, Nizamettin Gul, Edward Eitzen, George Oyler, Brian Molles

    Pages 291-342

15. Back Matter

    Pages 343-345

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Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

• botox
• botulinum neurotoxin
• botulism
• dysport
• neurotoxin complex
• neurotoxin-associated proteins
• oculinum
• recombinant protein
• therapeutic agent

• Units 4-10, Syntaxin Ltd., Abingdon, United Kingdom

  Keith A. Foster

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