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Hypoxia and Cancer

Biological Implications and Therapeutic Opportunities

  • Book
  • © 2014

Overview

Editors:
  1. Giovanni Melillo

    1. Bristol-Myers Squibb, Princeton, USA

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  • Features ?comprehensive and systematic analysis of biological and therapeutic targets associated with intra-tumor hypoxia
  • Focuses on translational aspects associated with intra-tumor hypoxia
  • Explores the opportunities for drug development offered by this unique feature of the tumor microenvironments
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Biology

    1. Front Matter

      Pages 1-1
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    2. Hypoxia and Breast Cancer Metastasis

      • Luana Schito, Gregg L. Semenza
      Pages 3-19

    3. Hypoxia and the DNA Damage Response

      • Monica M. Olcina, Ester M. Hammond
      Pages 21-41

    4. Emerging Roles of Non-Coding RNAs in the Hypoxic Response

      • Mircea Ivan, Xiaoling Zhong, Simona Greco, Fabio Martelli
      Pages 43-64

    5. Hypoxia and Reactive Oxygen Species

      • Agnes Görlach
      Pages 65-90

    6. Hypoxia and Gene Expression

      • Maria Carla Bosco, Luigi Varesio
      Pages 91-119

    7. Carbonic Anhydrase IX: From Biology to Therapy

      • Silvia Pastorekova, Claudiu T. Supuran
      Pages 121-153

  3. Imaging

    1. Front Matter

      Pages 155-155
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    2. Imaging the Hypoxic Tumor Microenvironment in Preclinical Models

      • Mary-Keara Boss, Gregory M. Palmer, Mark W. Dewhirst
      Pages 157-178

    3. Clinical Imaging of Hypoxia

      • Michael R. Horsman, Morten Busk, Thomas Nielsen, Marianne Nordsmark, Jens Overgaard
      Pages 179-201

  4. Therapy

    1. Front Matter

      Pages 203-203
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    2. Hypoxia, Metastasis, and Antiangiogenic Therapies

      • Dietmar W. Siemann, Yao Dai, Michael R. Horsman
      Pages 205-227

    3. The Unfolded Protein Response and Therapeutic Opportunities

      • Carly M. Sayers, Souvik Dey, Stacey L. Lehman, Constantinos Koumenis
      Pages 229-251

    4. Small Molecules Targeting the VHL/Hypoxic Phenotype

      • Raymond J. Louie, Mercè Padró, Amato J. Giaccia, Denise A. Chan
      Pages 253-264

    5. Hypoxia and Radiation Therapy

      • Marianne Nordsmark, Jan Alsner, Morten Busk, Jens Overgaard, Michael R. Horsman
      Pages 265-281

    6. Prodrug Strategies for Targeting Tumour Hypoxia

      • William R. Wilson, Kevin O. Hicks, Jingli Wang, Frederik B. Pruijn
      Pages 283-328

    7. Exploiting “Hif Addiction” For Cancer Therapy

      • Nicole D. Fer, Annamaria Rapisarda
      Pages 329-341

    8. Clinical Exploitation of Hypoxia

      • Geoff S Higgins, Adrian L Harris
      Pages 343-359

  5. Back Matter

    Pages 361-363
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Keywords

About this book

​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. 

This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.

Editors and Affiliations

  • Bristol-Myers Squibb, Princeton, USA

    Giovanni Melillo

About the editor

Dr. Giovanni Melillo is the Medical Director for the branch of Discovery Medicine at Bristol-Myers Squibb. Prior to his role at BMS, he was the Senior Investigator and Head of the Tumor Hypoxia Lab at the Developmental Therapeutics Program of the National Cancer Institute. He's been investigating hypoxia and its role in tumor progression for over 15 years. He's currently an Associate Editor for several journals, including Journal of Cancer Research and the Journal of Molecular Medicine. He also serves on the Editorial Board of several journals, including Cell Cycle and the Journal of Molecular Cancer, to name a few.

Bibliographic Information

  • Book Title: Hypoxia and Cancer

  • Book Subtitle: Biological Implications and Therapeutic Opportunities

  • Editors: Giovanni Melillo

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4614-9167-5

  • Publisher: Humana New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4614-9166-8Published: 10 November 2013

  • Softcover ISBN: 978-1-4939-5355-4Published: 23 August 2016

  • eBook ISBN: 978-1-4614-9167-5Published: 09 November 2013

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XIV, 363

  • Number of Illustrations: 17 b/w illustrations, 36 illustrations in colour

  • Topics: Cancer Research, Molecular Medicine, Pharmacology/Toxicology, Stem Cells

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