Testosterone: From Basic Research to Clinical Applications

1. Front Matter

   Pages i-xi

   PDF

2. History of Masculinization

   • Lee B. Smith, Iain J. McEwan

   Pages 1-7

3. Recent Understanding of Masculinization

   • Lee B. Smith, Iain J. McEwan

   Pages 9-16

4. Where Does Testosterone Come from and How Does It Act?

   • Lee B. Smith, Iain J. McEwan

   Pages 17-27

5. Androgen Receptor Signaling in the Testis

   • Lee B. Smith, Iain J. McEwan

   Pages 29-35

6. Androgen Signaling in Other Body Systems

   • Lee B. Smith, Iain J. McEwan

   Pages 37-57

7. Manipulating Androgens for Therapy

   • Lee B. Smith, Iain J. McEwan

   Pages 59-69

8. Back Matter

   Pages 71-73

   PDF

This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.

• Androgen Receptor
• Endocrinology
• Fertility
• Masculinization
• Testis Function
• Testosterone

• MRC Centre for Reproductive Health The Queen’s Medical Research Council, University of Edinburgh, Edinburgh, United Kingdom

  Lee B. Smith

• MRC Center for Reproductive Health, Queens Medical Research Institute University of Edinburgh, Edinburgh, United Kingdom

  Rod T. Mitchell

• School of Medical Sciences, University of Aberdeen Inst. Medical Sciences, Aberdeen, United Kingdom

  Iain J. McEwan

Policies and ethics