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Cholesterol and Presynaptic Glutamate Transport in the Brain

  • Book
  • © 2013

Overview

Authors:
  1. Tatiana Borisova

    1. Department of Neurochemistry, Palladin Institute of Neurochemistry NAS of Ukraine, Kiev, Ukraine

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  • Reviews the literature on the role of cholesterol in brain function
  • Examines the neuroprotective aspects of lower cholesterol
  • Medical doctors will be especially interested in the data on statins?
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Neuroscience (BRIEFSNEUROSCI, volume 12)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Presynaptic Glutamate Transport in the Brain

    • Tatiana Borisova
    Pages 1-8

  3. Cholesterol and Its Role in Synaptic Transmission

    • Tatiana Borisova
    Pages 9-14

  4. Effects of Cholesterol-Depleting Agent Methyl-β-Cyclodextrin on the Functional State of Brain Nerve Terminals

    • Tatiana Borisova
    Pages 15-23

  5. The Extracellular Level and Uptake of Glutamate in Cholesterol-Deficient Nerve Terminals

    • Tatiana Borisova
    Pages 25-37

  6. Unstimulated and Exocytotic Glutamate Release from Cholesterol-Deficient Nerve Terminals

    • Tatiana Borisova
    Pages 39-56

  7. Neuroprotection by Lowering Cholesterol

    • Tatiana Borisova
    Pages 57-68

  8. Back Matter

    Pages 69-75
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Keywords

About this book

Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders.  Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity.   In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits.​

Authors and Affiliations

  • Department of Neurochemistry, Palladin Institute of Neurochemistry NAS of Ukraine, Kiev, Ukraine

    Tatiana Borisova

Bibliographic Information

  • Book Title: Cholesterol and Presynaptic Glutamate Transport in the Brain

  • Authors: Tatiana Borisova

  • Series Title: SpringerBriefs in Neuroscience

  • DOI: https://doi.org/10.1007/978-1-4614-7759-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Softcover ISBN: 978-1-4614-7758-7Published: 07 July 2013

  • eBook ISBN: 978-1-4614-7759-4Published: 06 July 2013

  • Series ISSN: 2191-558X

  • Series E-ISSN: 2191-5598

  • Edition Number: 1

  • Number of Pages: XVI, 75

  • Number of Illustrations: 21 b/w illustrations, 11 illustrations in colour

  • Topics: Neurosciences, Neurochemistry

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