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Protein Kinase CK2 — From Structure to Regulation

  • Book
  • © 2001

Overview

Editors:
  1. Khalil Ahmed

    1. Cellular and Molecular Biochemistry Research Lab, University of Minnesota, Veterans Affairs Medical Center, Minneapolis, USA

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  2. Olaf-Georg Issinger

    1. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

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  3. Jorge E Allende

    1. Program de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla, Santiago 7, Chile

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Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 35)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-2
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  2. Characterization of CK2 holoenzyme variants with regard to crystallization

    • Barbara Guerra, Karsten Niefind, Inessa Ermakowa, Olaf-Georg Issinger
    Pages 3-11

  3. Generation of mutants of CK2α which are dependent on the β-subunit for catalytic activity

    • Stefania Sarno, Paola Ghisellini, Luca Cesaro, Roberto Battistutta, Lorenzo A. Pinna
    Pages 13-19

  4. Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners

    • David W. Litchfield, Denis G. Bosc, David A. Canton, Ronald B. Saulnier, Greg Vilk, Cunjie Zhang
    Pages 21-29

  5. A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin

    • María J. Benítez, Claude Cochet, Juan S. Jiménez
    Pages 31-36

  6. The activity of CK2 in the extracts of COS-7 cells transfected with wild type and mutant subunits of protein kinase CK2

    • Iris Korn, Germaine Jacob, Catherine C. Allende, Jorge E. Allende
    Pages 37-44

  7. Transcriptional coordination of the genes encoding catalytic (CK2α) and regulatory (CK2β) subunits of human protein kinase CK2

    • Walter Pyerin, Karin Ackermann
    Pages 45-57

  8. Genes targeted by protein kinase CK2: A genome-wide expression array analysis in yeast

    • Karin Ackermann, Andrea Waxmann, Claiborne V. C. Glover, Walter Pyerin
    Pages 59-66

  9. Consequences of CK2 signaling to the nuclear matrix

    • Shihui Yu, Huamin Wang, Alan Davis, Khalil Ahmed
    Pages 67-71

  10. Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus

    • Michael Faust, Martin Jung, Jürgen Günther, Richard Zimmermann, Mathias Montenarh
    Pages 73-80

  11. Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells

    • Véronique Martel, Odile Filhol, Arsenio Nueda, Delphine Gerber, Maria Jose Benitez, Claude Cochet
    Pages 81-90

  12. Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2

    • Regina L. Trott, Madhavi Kalive, Umesh Karandikar, Rebecca Rummer, Clifton P. Bishop, Ashok P. Bidwai
    Pages 91-98

  13. A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2

    • Madhavi Kalive, Regina L. Trott, Ashok P. Bidwai
    Pages 99-105

  14. Environmental reprogramming of the expression of protein kinase CK2β subunit in fish

    • Marco Alvarez, Gudrun Kausel, Jaime Figueroa, María Inés Vera
    Pages 107-112

  15. Mutation at the CK2 phosphorylation site on Cdc28 affects kinase activity and cell size in Saccharomyces cerevisiae

    • Gian Luigi Russo, Christian van den Bos, Daniel R. Marshak
    Pages 113-117

  16. Distinctive features of plant protein kinase CK2

    • Marta Riera, Giovanna Peracchia, Montserrat Pagès
    Pages 119-127

  17. Cloning and characterization of the cDNA coding for the catalytic α subunit of CK2 from tobacco

    • Paula Salinas, Brigitte Bantignies, Julio Tapia, Xavier Jordana, Loreto Holuigue
    Pages 129-135

  18. Regulation of the human papillomavirus oncoproteins by differential phosphorylation

    • Paola Massimi, David Pim, Christian Kühne, Lawrence Banks
    Pages 137-144

  19. HIV-1 Rev transactivator: A β-subunit directed substrate and effector of protein kinase CK2

    • Flavio Meggio, Oriano Marin, Marco Boschetti, Stefania Sarno, Lorenzo A. Pinna
    Pages 145-151

  20. Protein kinase CK2: Signaling and tumorigenesis in the mammary gland

    • Esther Landesman-Bollag, Diane H. Song, Raphaelle Romieu Mourez, Daniel J. Sussman, Robert D. Cardiff, Gail E. Sonenshein et al.
    Pages 153-165
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Keywords

About this book

CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation.

This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.

Editors and Affiliations

  • Cellular and Molecular Biochemistry Research Lab, University of Minnesota, Veterans Affairs Medical Center, Minneapolis, USA

    Khalil Ahmed

  • Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

    Olaf-Georg Issinger

  • Program de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla, Santiago 7, Chile

    Jorge E Allende

Bibliographic Information

  • Book Title: Protein Kinase CK2 — From Structure to Regulation

  • Editors: Khalil Ahmed, Olaf-Georg Issinger, Jorge E Allende

  • Series Title: Developments in Molecular and Cellular Biochemistry

  • DOI: https://doi.org/10.1007/978-1-4615-1723-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-7923-7666-8Published: 30 June 2002

  • Softcover ISBN: 978-1-4613-5696-7Published: 22 March 2013

  • eBook ISBN: 978-1-4615-1723-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: V, 187

  • Additional Information: Reprinted from MOLECULAR AND CELLULAR BIOCHEMISTRY, 227:1-2

  • Topics: Biochemistry, general

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