Molecular Basis of Pancreas Development and Function

1. Front Matter

   Pages i-xiii

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2. An Historical and Phylogenetic Perspective of Islet-Cell Development

   • Ole D. Madsen, Palle Serup, Jan Jensen, Helle V. Petersen, R. Scott Heller

   Pages 1-17

3. Glucose signalling to Transcription factors of the Insulin gene

   • Danielle Melloul

   Pages 19-33

4. β-Cell Dysfunction and Chronic Hyperglycaemia

   • Jack L. Leahy

   Pages 35-46

5. Glucose Toxicity of the Pancreatic ß-Cell

   • R. Paul Robertson, Jamie Harmon, Yoshito Tananka, Giovanni Sacchi, Phuong Oanh T. Tran, Catherine Gleason et al.

   Pages 47-66

6. The α-Cell and Regulation of Glucagon Gene Transcription

   • Willchart Knepel

   Pages 67-89

7. The KATP Channel and the Sulfonylurea Receptor

   • Susumu Seino, Takashi Miki, Hideki Yano

   Pages 91-107

8. Glucagon-Like Peptide-1: An Insulinotropic Hormone With Potent Growth Factor Actions at the Pancreatic Islets of Langerhans

   • George G. Holz, Colin A. Leech

   Pages 109-141

9. Communication of Islet Cells: Molecules and Functions

   • Paolo Meda, Domenico Bosco

   Pages 143-163

10. Soluble Factors Important for Pancreas Development

    • Raphael Scharfmann, Paul Czernichow

    Pages 165-175

11. Role of Mesenchymal-Epithelial Interactions in Pancreas Development

    • Thomas S. Maldonado, Christopher A. Crisera, Alan S. Kadison, Michael T. Longaker, George K. Gittes

    Pages 177-195

12. Homeodomain Proteins in Pancreas Development

    • Ulf Ahlgren, Helena Edlund

    Pages 197-212

13. bHLH Factors and Notch in Pancreatic Development

    • Jan Jensen, Luis Emilio Flores, R. Scott Heller, Palle Serup, Ole D. Madsen

    Pages 213-227

14. Identification, Biological Functions, and Contribution to Human Diabetes of Islet-Brain 1

    • Gérard Waeber, Christophe Bonny

    Pages 229-238

15. Pax4 and Pax6 in Islet Differentiation

    • Xunlei Zhou, Peter Gruss

    Pages 239-254

16. The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis

    • Markus Stoffel

    Pages 255-274

17. Regulation of pdx-1 Gene Expression

    • Kevin Gerrish, Susan Samaras, Michelle A. Cissell, Christopher V.E. Wright, Roland Stein

    Pages 275-287

18. Mechanisms of Postnatal β-Cell Mass Regulation

    • Susan Bonner-Weir, Gordon C. Weir

    Pages 289-297

19. Genetic models of Insulin Resistance:Alterations in β-cell biology

    • Rohit N. Kulkarni, C. Ronald Kahn

    Pages 299-323

20. Clinical Consequences of Defects in β-Cell Genes

    • Julie C. Evans, Timothy M. Frayling, Andrew T. Hattersley

    Pages 325-336

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.

• Pancreas
• Pancreatic Islets
• biology
• diabetes
• diabetes mellitus
• growth
• growth factor
• homeostasis
• hormone
• insulin
• insulin resistance
• pathophysiology
• physiology
• protein

`A very interesting text for both research and clinical endocrinologists.'
Journal of Pediatric Endocrinology and Metabolism, 15:4 (2002)

• Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston

  Joel F. Habener

• Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York

  Mehboob A. Hussain

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