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Evolving Concepts in Sepsis and Septic Shock

  • Book
  • © 2001

Overview

Editors:
  1. Peter Q. Eichacker

    1. Critical Care Medicine Department, Warren Grant Magnuson Clinical Center National Institutes of Health, Bethesda, USA

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  2. Jérôme Pugin

    1. Division of Medical Intensive Care, University Hospital of Geneva, Geneva 14, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Perspectives on Critical Care Infectious Diseases (CCID, volume 2)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Sepsis Definitions

    • Javier Pérez, R. Phillip Dellinger
    Pages 1-15

  3. Definitions: Sepsis Versus SIRS

    • Jean-Louis Vincent
    Pages 17-25

  4. Toll-Like Receptors

    • Jérôme Pugin
    Pages 27-44

  5. Macrophage Migration Inhibitory Factor (MIF): A Pro-Inflammatory Mediator of Sepsis

    • Christian Martin, Thierry Roger, Thierry Calandra
    Pages 45-67

  6. Genetic Susceptibility to Infection and Sepsis

    • Bradley D. Freeman, Barbara A. Zehnbauer
    Pages 69-79

  7. Impact of Genomic Variations on Inflammatory Processes and Sepsis

    • Frank Stüber
    Pages 81-95

  8. Corticosteroids in Sepsis

    • Sergey Goodman, Charles L. Sprung
    Pages 97-109

  9. The Bidirectional Effect of Inflammation on Bacterial Growth: A New Insight into the Role of Glucocorticoids in the Resolution of Severe Infections

    • G. Umberto Meduri
    Pages 111-127

  10. Anti-Inflammatory Therapy in Sepsis

    • Jonathan Sevransky, Charles Natanson
    Pages 129-143

  11. Perspectives in Anti-Inflammatory Therapies in Sepsis

    • Jean-François Dhainaut, Nathalie Marin, Alain Cariou
    Pages 145-161

  12. Immunostimulation in Sepsis

    • Hans-Dieter Volk, Kerstin Wolk, Robert Sabat, Wolf-Dietrich Döcke, Petra Reinke
    Pages 163-174

  13. Granulocyte Colony Stimulating Factor as a Therapy for Pneumonia and Sepsis in the Nonneutropenic Host: Preclinical and Clinical Trials

    • Chantal Parent, Peter Q. Eichacker
    Pages 175-187

  14. Back Matter

    Pages 189-195
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Keywords

About this book

Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection.
While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.

Editors and Affiliations

  • Critical Care Medicine Department, Warren Grant Magnuson Clinical Center National Institutes of Health, Bethesda, USA

    Peter Q. Eichacker

  • Division of Medical Intensive Care, University Hospital of Geneva, Geneva 14, Switzerland

    Jérôme Pugin

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