Gossypol

1. Front Matter

   Pages i-xiii

   PDF

2. Introduction and History of Gossypol

   1. Introduction and History of Gossypol

      • Sheldon J. Segal

      Pages 1-7

3. Studies with Human Subjects and Non-Human Primates

   1. Trial of Gossypol as a Male Contraceptive

      • Guo-zhen Liu, Katherine C. Lyle, Jian Cao

      Pages 9-16

   2. Effect of Gossypol on Human Testicular Function: Evaluation of Seminal and Hormonal Parameters

      • Julian Frick, C. Danner

      Pages 17-23

   3. Biphasic Action of Gossypol in Men

      • Elsimar M. Coutinho, Sheldon J. Segal, Jose F. Melo, Ione Barbosa

      Pages 25-31

   4. Effect of Gossypol on the Fertility of the Male Bonnet Monkey

      • Natwar R. Kalla, J. Foo, T. W. Kalpana, S. Hurkadli, A. R. Shetht

      Pages 33-43

4. Toxicity and Teratogenicity Studies in Animals

   1. Assessment of Toxicity and Antifertility Efficacy of Gossypol in Male Rats

      • Chin-Chuan Chang, Sheldon J. Segal

      Pages 45-57

   2. The Arrhythomogenic Effect of Gossypol in the Rat Heart

      • Wei-min Huang, Charles R. Katholi, W. T. Woods

      Pages 59-66

   3. Gossypol Studies in Male Rats

      • Chin-Chuan Chang, Zhiping Gu, Yun-Yen Tsong

      Pages 67-77

   4. Embryonic and Reproductive Toxicity Evaluation of Gossypol

      • Gerhard F. Weinbauer, Natwar R. Kalla, Julian Frick

      Pages 79-88

   5. A Reproduction and Teratology Study with Gossypol

      • Allan R. Beaudoin

      Pages 89-109

5. Mechanism of Action studies in vivo

   1. Effect of Gossypol on Prostatic Androgen Receptors in Male Rats

      • Natwar R. Kalla, Erwin Rovan, Gerhard F. Weinbaue, Julian Frick

      Pages 111-117

   2. Effect of Gossypol on Accumulation of Rhodamine-123 by Sertoli Cell Mitochondria

      • Nongnuj Tanphaichitr, Anthony R. Bellvé

      Pages 119-141

   3. Ultrastructural, Biochemical, and Endocrine Studies on the Effects of Gossypol and its Isomeric Derivatives on The Male Reproductive Tract

      • Anita P. Hoffer

      Pages 143-186

   4. A Solid Phase Radioimmunoassay for Gossypol

      • Y. Y. Tsong, C. C. Chang

      Pages 187-201

6. Mechanism of Action Studies in Vitro

   1. Evaluation of Gossypol’s Effect on Bull Spermatozoa in Vitro

      • Erwin Rovan, Natwar R. Kalla, Julian Frick, H. Adam

      Pages 203-213

   2. Influence of Gossypol on the Motility and Dynein ATPase Activity of Sea Urchin Sperm

      • Hideo Mohri, Sheldon J. Segal, Samuel S. Koide

      Pages 215-226

   3. Binding of [¹⁴C]Gossypol byArbacia Sperm

      • Eimei Sato, Sheldon J. Segal, Samuel S. Koide

      Pages 227-235

   4. Biochemical Studies of Gossypol

      • Chi-Yu Gregory Lee, Young S. Moon, Anthony Duleba, Albert F. Chen, James H. Yuan, Victor Gomel

      Pages 237-244

   5. Deactivation of Spermatozoal Fertilizing Capability by Gossypol

      • Wung-Wai Tso

      Pages 245-255

The search for a reversible male contraceptive has centered upon the suppression of sperm production or sperm motility. Gossypol, a natural substance extracted from the cotton plant, appears to cause both of these effects. Its ability to reduce spermatogenesis in men is undeniable and has been demonstrated in both large studies in China and a smaller confirmatory study in Brazil. These investiga­ tions have revealed the remarkable fact that with gossypol, it is possible to separate an effect on the testis' gamete-producing function from an effect on its hormone-producing function. Thus, it is possible to maintain normal testosterone levels and libido while sperm counts (and motility) fall. Because of this unique and important action, gossypol warrants the fullest possible evaluation as a potential male contraceptive. Sheldon J. Segal vii ACKNOWLEDGMENT Lynn C. Landman played a major role in this publication by skillfully editing the manuscripts which were submitted for inclusion in this volume. Janet O'Connell added her efforts in editing, assembling texts and figures and handling final details required for publication. I thank these talented colleagues for their invaluable contributions.

• assessment
• cell
• heart
• leukemia

• The Rockeller Foundation, New York, USA

  Sheldon J. Segal

Policies and ethics