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Manipulation of Mammalian Development

  • Book
  • © 1986

Overview

Editors:
  1. Ralph B. L. Gwatkin

    1. The Cleveland Clinic Foundation, Cleveland, USA

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Part of the book series: Developmental Biology (DEBO, volume 4)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Gene Transfer into Mouse Embryos

    • Katherine Gordon, Frank H. Ruddle
    Pages 1-36

  3. Nuclear and Cytoplasmic Transfer in Mammalian Embryos

    • James McGrath, Davor Solter
    Pages 37-55

  4. Oocyte Fusion

    • Bela J. Gulyas
    Pages 57-80

  5. Animal in Vitro Fertilization and Embryo Development

    • Barry D. Bavister
    Pages 81-148

  6. Recent Progress in Human in Vitro Fertilization and Embryo Transfer

    • Alan Trounson
    Pages 149-194

  7. Embryo Sexing of Farm Animals

    • W. C. D. Hare
    Pages 195-216

  8. Cryopreservation of Mammalian Eggs and Embryos

    • Ian Wilmut
    Pages 217-247

  9. Embryo Transfer in Animals

    • Frank B. Kuzan, George E. Seidel Jr.
    Pages 249-278

  10. Manipulation of Early Mammalian Development: What Does It Tell Us about Cell Lineages?

    • Martin H. Johnson
    Pages 279-296

  11. Tissue Interactions in Development of Teeth and Related Ectodermal Derivatives

    • Edward J. Kollar
    Pages 297-313

  12. Tissue Combination and Organ Culture Studies in the Development of the Embryonic Mammary Gland

    • Klaus Kratochwil
    Pages 315-333

  13. Immunogenetic Approaches to the Analysis of Mammalian Development

    • Susan Heyner
    Pages 335-352

  14. The Immunological Approach to the Study of Preimplantation Mammalian Development

    • Carole L. Banka, Patricia G. Calarco
    Pages 353-381

  15. Back Matter

    Pages 383-388
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Keywords

About this book

Developmental biology has been transformed recently by discoveries in the fields of molecular biology, cell biology, and immunology. New ways of manip­ ulating mammalian development are uncovering control mechanisms and ena­ bling us to apply them in solving practical problems in animal production and human health. This book outlines some of these new manipulations and how they have contributed to the present state of developmental biology. Chapter 1 describes gene transfer by micro injection of cloned recombinant DNA into zygotes. Although the factors that affect transformation frequencies and integration sites are still unknown, such techniques offer a number of exciting prospects. Research models for human disease coula be artificially created and desirable characteristics in agricultural animals could be - hanced. . The theme of cell-to-cell transfer is continued in Chapters 2 and 3. Chapter 2 describes pronuclear transplantation by Sendai virus-induced fusion of the karyoplast with the enucleated embryo. Using this procedure, it has been dem­ onstrated that both male and female genomes are essential for normal develop­ ment, although the reason for this is not yet understood. Chapter 3 describes studies on the fusion of whole oocytes. .

Editors and Affiliations

  • The Cleveland Clinic Foundation, Cleveland, USA

    Ralph B. L. Gwatkin

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