Renal Stone Disease

1. Front Matter

   Pages i-xvii

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2. Physicochemistry of Urinary Stone Formation

   • Neil S. Mandel, Gretchen S. Mandel

   Pages 1-24

3. Pathogenesis of Hypercalciuria

   • Joseph E. Zerwekh

   Pages 25-45

4. Pathophysiology of Nonhypercalciuric Causes of Stones

   • Neil A. Breslau, Khashayar Sakhaee

   Pages 47-84

5. Nutritional Aspects of Stone Disease

   • Laurie Wainer, Vicki A. Resnick, Martin I. Resnick

   Pages 85-120

6. Radiologic Considerations

   • Linda O. Judge

   Pages 121-142

7. Diagnostic Considerations

   • Glenn M. Preminger, Jean A. Harvey

   Pages 143-164

8. Prevention of Recurrent Nephrolithiasis

   • Charles Y. C. Pak

   Pages 165-199

9. Potassium Citrate Therapy of Nephrolithiasis

   • Charles Y. C. Pak, Beverley V. Adams

   Pages 201-224

10. Struvite Stones

    • John S. Rodman

    Pages 225-251

11. Contemporary Approaches to Removal of Renal and Ureteral Calculi

    • Donald P. Griffith, Randall B. Meacham

    Pages 253-271

12. Back Matter

    Pages 273-277

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CHARLES Y. c. PAK Major progress has been made in the pathophysiologic elucidation and management of nephrolithiasis during the past two decades. It is now possible to detect the cause of stone disease in more than 95% of patients, to prevent recurrent formation of stones in the majority of patients, and to remove most existing stones less invasively. The assumption of editorship of this book permits me to indulge in the discussion of this progress from my personal perspective. Three somewhat fortuitous events in my academic career dictated my directing major efforts in stone research. The first event occurred in 1963 when, after having completed medical training, I was faced with two years of military service as a participant of the Berry plan. Choices were limited and disconcerting for someone interested in a research career: a staff physician at a military installation or an indian reservation, or a member of a research team in a state penitentiary. An interesting article by Norman Gershfeld on phospholi­ pid monolayers prompted me to write him seeking a position in his laboratory of Health (NIH) in Bethesda, MD. Partly because of at the National Institutes my rudimentary exposure and publication in surface chemistry, I was offered a position as a staff scientist and a position in the Public Health Service which satisfied the requirements of a military service.

• Laboratory
• chemistry
• health
• management
• nutrition
• pathogenesis
• pathophysiology
• patients
• physiology
• prevention
• public health
• research
• therapy
• training
• treatment
• diabetes

• Center in Mineral Metabolism and Clinical Research, University of Texas Health Science Center at Dallas, Dallas, USA

  Charles Y. C. Pak

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