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Molecular Mechanisms of Alcohol

Neurobiology and Metabolism

  • Book
  • © 1989

Overview

Editors:
  1. Grace Y. Sun

    1. Sinclair Research Farm, University of Missouri, Columbia, USA

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  2. P. Kevin Rudeen

    1. Department of Anatomy and Neurobiology, University of Missouri, Columbia, USA

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  3. W. Gibson Wood

    1. VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, USA

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  4. Yau-Huei Wei

    1. Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

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  5. Albert Y. Sun

    1. Sinclair Research Farm, University of Missouri, Columbia, USA

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Part of the book series: Experimental Biology and Medicine (EBAM, volume 21)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Ethanol Action on Neurochemical Mechanisms

    1. Front Matter

      Pages 1-1
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    2. Specific Action of Ethanol on Lateral and Vertical Membrane Lipid Domains

      • W. G. Wood, C. Gorka, A. M. Rao, F. Schroeder
      Pages 3-13

    3. Effects of Acute and Chronic Ethanol Administration on Metabolism of Brain Acidic Phospholipids

      • Grace Y. Sun, Renuka Chandrasekhar, Hsueh-Meei Huang
      Pages 15-38

    4. Effects of Ethanol on Receptors Coupled to Phosphoinositide Hydrolysis in Brain

      • Fulton T. Crews, Norbert J. Pontzer, L. Judson Chandler
      Pages 39-55

    5. The Effects of Ethanol on Synaptic Membrane Calcium Transporting Systems

      • Mary L. Michaelis
      Pages 57-67

    6. Depolarization-Dependent Poly-Phosphoinositide Hydrolysis in Brain is Inhibited by Ethanol In Vitro

      • Ruben A. Gonzales
      Pages 69-74

    7. Glutamic Acid Synaptic Activity is a Target of Acute and Chronic Ethanol Effects in the Mammalian Brain

      • Elias K. Michaelis
      Pages 75-86

    8. Effect of Ethanol Administration on the Phosphorylation of a 43KDa Synaptosomal Protein

      • P. M. Wixom, A. Y. Sun
      Pages 87-95

    9. Ethanol Alters Monoamine Content in Different Brain Regions of Spontaneously Hypertensive Rats

      • Ying-Ling Wang, Jiann-Wu Wei
      Pages 97-105

    10. Synthesis of Fatty Acid Ethyl Esters by Brain Membranes

      • Teng-nan Lin, Grace Y. Sun
      Pages 107-118

    11. Vasopressin and Ethanol Tolerance: Postulated Mechanism for Neuroadaptation

      • Paula L. Hoffman, Hideaki Ishizawa, Gyula Szabó, J. R. Dave, Li-Ing Liu, Boris Tabakoff
      Pages 119-131

    12. Serotonergic Mechanisms in Alcohol Intake

      • David T. Wong, James M. Murphy
      Pages 133-146

    13. Mechanisms of Central Nervous System Alcohol-Related Birth Defects

      • P. Kevin Rudeen, Julia A. Creighton
      Pages 147-165

  3. Ethanol and Cell Culture

    1. Front Matter

      Pages 167-167
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    2. Prenatal Ethanol Studies on Astrocytes

      • Sujata Tewari, Thanh Hoang, David Winn, Kimberly Boyd, Hemalatha Parekh
      Pages 169-192

    3. Cell Cultures as a Model for Alcohol Research

      • Christer Alling, Elisabeth Hansson, Per Simonsson
      Pages 193-205

    4. Ethanol and Bradykinin-Stimulated Phosphoinositide Hydrolysis in NG108–15 Neuroblastoma-Glioma Cells

      • Per Simonsson, Grace Y. Sun, Christer Alling
      Pages 207-214

    5. Effect of Lipid Peroxidation on Glucose Transport in Astrocytes: Potentiation by Ethanol

      • T. C. Jou, S. M. Liu, A. Y. Sun
      Pages 215-224

  4. Ethanol Effects on Metabolism

    1. Front Matter

      Pages 225-225
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Keywords

About this book

Alcohol abuse throughout the world is associated with serious social and medical implications. Problems such as intoxication, tol­ erance, and development of physical dependence have been well recognized. The central nervous system and the liver are especially affected. There is little doubt that alcohol abuse can result in organ damage, which in turn leads to deleterious health consequences to the individual. Understanding ethanol action presents a special and functional diver­ challenge because of its molecular simplicity sity. In fact, the ability for alcohol to disrupt cellular function is at­ tributed to its cellular injury without regard to an apparent specific mechanism of action. Nevertheless, the key to an effective treatment to this problem is through research into understanding the mechan­ isms underlying how ethanol interacts with cells and membranes. This book is the result of a cooperative effort among scientists from many nations who met in a symposium in Taipei, Taiwan, ROC, July 1988. The focus of this book is on experimental ap­ proaches to better understand the molecular mechanisms of ethanol on the biological system. These recent advances in the examination of the alcohol effects on cellular function are divided into four sec­ tions. The first section addresses specific actions of ethanol on the central nervous system. The second section is directed to the use of cell cuI tures in ethanol research and the usefulness of cell cultures in examination of the effects of ethanol in vitro.

Editors and Affiliations

  • Sinclair Research Farm, University of Missouri, Columbia, USA

    Grace Y. Sun, Albert Y. Sun

  • Department of Anatomy and Neurobiology, University of Missouri, Columbia, USA

    P. Kevin Rudeen

  • VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, USA

    W. Gibson Wood

  • Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

    Yau-Huei Wei

Bibliographic Information

  • Book Title: Molecular Mechanisms of Alcohol

  • Book Subtitle: Neurobiology and Metabolism

  • Editors: Grace Y. Sun, P. Kevin Rudeen, W. Gibson Wood, Yau-Huei Wei, Albert Y. Sun

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-4514-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1989

  • Hardcover ISBN: 978-0-89603-170-8Published: 26 October 1989

  • Softcover ISBN: 978-1-4612-8855-8Published: 17 September 2011

  • eBook ISBN: 978-1-4612-4514-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 398

  • Topics: Neurosciences

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