Protein Structure

1. Front Matter

   Pages i-xi

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2. Welcome & Introduction

   1. Welcome & Introduction

      • Terence Barrett

      Pages 1-2

3. Protein Structure and Microconformations

   1. Debye-Waller Factor in Solid State and Biological Samples

      • E. Stern

      Pages 3-15

   2. Anharmonicity and Debye-Waller Factors in Biomolecules

      • J. Krumhansl

      Pages 17-30

   3. Proteins as Fractals

      • H. Stapleton

      Pages 31-45

4. Dynamics of Protein Structure

   1. Configurational Entropy and Dielectric Relaxations in Proteins

      • L. Dissado

      Pages 47-63

   2. The Mössbauer Effect as a Probe of Protein Dynamics

      • F. Parak, H. Hartmann, G. Nienhaus

      Pages 65-84

   3. The Protein as a Glass

      • D. Stein

      Pages 85-93

   4. Rayleigh Scattering of Mössbauer Radiation (RSMR): Data, Hydration Effects and Glass-like Dynamical Model of Biopolymers

      • V. I. Gol’danskii, Y. F. Krupyanskii, V. N. Fleurov

      Pages 95-138

   5. Dynamics and Function in Cytochrome c by Two-dimensional NMR

      • S. Englander, H. Roder, A. Wand

      Pages 139-153

   6. Panel Discussion: How Rigid are Proteins and Do We Care?

      • Peter Debrunner

      Pages 155-166

5. The Role of Protein Structure and Reactivity

   1. Low Temperature Biophysics and Room Temperature Biology

      • J. J. Hopfield

      Pages 167-185

   2. Protein Vibrations Can Markedly Affect Reaction Kinetics: Interpretation of Myoglobin-CO Recombination

      • W. Bialek, R. Goldstein

      Pages 187-199

   3. Adiabaticity Criteria in Biomolecular Reactions

      • P. Wolynes

      Pages 201-209

   4. Structural Dynamics and Reactivity in Hemoglobin

      • J. Friedman, B. Campbell

      Pages 211-243

   5. The Connection Between Low-Temperature Kinetics and Life

      • H. Frauenfelder

      Pages 245-261

   6. Panel Discussion: The Role of Protein Structure, Dynamics and Ligand Reactivity

      • Robert Austin

      Pages 263-276

6. Charge Exchange in Proteins and Model Systems

   1. Charge Exchange Between Localized Sites

      • J. Jortner, M. Bixon

      Pages 277-308

   2. The Effect of Conformational Dynamics and Phase Transitions on Electron and Atom Group Transfer Processes

      • A. M. Kuznetsov, J. Ulstrup

      Pages 309-327

   3. Effects of Distance, Energy and Molecular Structure on Electron Transfer Rates

      • J. Miller

      Pages 329-338

This book is concerned with the physical aspects of molecular and electronic tunneling in biological systems, and the extent to which protein structure controls these events. The scope is very broad and this volume could almost be a textbook in biophysics. Both fundamental processes and the extrapolation to physiological events are stressed. The discussion sections are remarkably frank and offer insight into the basic problems confronting physists and chemists as they seek to apply their techniques to biological systems. This book on the physics of biomolecules reflects recent progress in understanding the biological function of the key protein molecules from detailed knowledge of their physics. New and exciting are the glasslike aspects of protein structures and the discussion of proteins as fractals. Other topics dealt with are low-temperature kinetics and reactivity, structure and charge exchange, and charge separation in photosynthetic reaction centers.

• biomolecules
• biophysics
• protein
• protein structure
• proteins
• temperature

• Princeton University, Princeton, USA

  Robert Austin

• B.F. Goodrich Co., Brecksville, USA

  Ephraim Buhks

• University of Pennsylvania, Philadelphia, USA

  Britton Chance, Paul Leslie Dutton

• University of Illinois, Urbana, USA

  Don Vault, Hans Frauenfelder

• Academy of Sciences of the USSR, Moscow, USSR

  Vitalli I. Gol’danskii

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