Autoimmune Reactions

1. Front Matter

   Pages i-xiv

   PDF

2. Diversity of Immunological Defects in Autoimmune Diseases

   • Sudhir Paul

   Pages 1-4

3. Insights into Mechanisms of Autoimmune Disease Based on Clinical Findings

   • Noel R. Rose

   Pages 5-17

4. Autoimmunity and B-Cell Malignancies

   • Otto Pritsch, Guillaume Dighiero

   Pages 19-30

5. Pathogenesis of Autoimmune Thyroid Disease

   • Ramzi A. Ajjan, Anthony P. Weetman

   Pages 31-59

6. Autoantigens of Sjögren’s Syndrome

   • Isao Nishimori, Michael A. Hollingsworth

   Pages 61-77

7. Autoimmunity in Patients with Essential Hypertension

   • Israel Rubinstein

   Pages 79-83

8. Autoimmune Antigen Presentation Mechanisms

   • Edward Dwyer

   Pages 85-97

9. Induction of Pathogenic Autoimmune T-Cell and Autoantibody Responses Through T-Cell Epitope Mimicry

   • Kenneth S. K. Tung, Kristine M. Garza, Ya-huan Lou

   Pages 99-112

10. T-Cell Antigen Receptor Repertoire in Rheumatoid Arthritis

    • James W. Edinger, David N. Posnett

    Pages 113-140

11. The Role of Exogenous Stimulation in Pathogenesis of Autoimmune Diseases

    • Constantin Bona, Chihiro Murai, Takeshi Sasaki

    Pages 141-155

12. Dysregulation of the Idiotype Network in Autoimmune Diseases

    • Haraldine A. Stafford, Morris Reichlin

    Pages 157-176

13. The Role of Variable Region Gene Rearrangements in the Generation of Autoantibodies

    • Anne Davidson

    Pages 177-190

14. Autoantibodies Against Ig Immunoglobulin Framework Epitopes

    • Heinz Kohler, Sybille Müller

    Pages 191-199

15. Autoantibodies to T-Cell Receptors

    • John J. Marchalonis, Samuel F. Schluter, David E. Yocum

    Pages 201-219

16. Autoantibody Catalysis

    • Sudhir Paul

    Pages 221-234

17. Is the Catalytic Activity of Bence Jones Proteins an Autoimmune Effector Mechanism in Multiple Myeloma?

    • Hyogo Sinohara, Kinji Matsuura

    Pages 235-247

18. Kidney Damage in Autoimmune Disease

    • Gerald C. Groggel

    Pages 249-268

19. DNA as Immunogen for the Induction of Immune and Autoimmune Antibody in Mice

    • Tony N. Marion

    Pages 269-292

20. Cellular Entry and Nuclear Localization of Anti-DNA Antibodies

    • Kumiko Yanase, Michael P. Madaio

    Pages 293-304

Autoimmune Reactions tackles fundamental questions about how the immune system can destroy invading microbial pathogens without causing damage to itself and other "self" systems. The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms. They also discusses possible general mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their current limitations as unifying explanations of the diseases described. The book illustrates the type of thinking and research that should eventually permit development of palliatives and cures for autoimmune diseases.

• Antigen
• antigen presentation
• autoimmune disease
• autoimmunity
• cell
• diseases
• immunoglobulin
• pathogenesis
• proteins

"...tackles fundamental questions about how the immune system can destroy invading microbial pathogens without causing damage to itself and other "self" systems.The authoritative expert writers explore the mechanistic aspects of...autoimmune diseases...and where possible, delineate how malfunctioning immunological mechanisms can lead to clinical symptoms. They also discuss possible general mechanisms of autoimmune disease...and their current limitations as unifying explanations of the disease described. The book illustrates the type of thinking and research that should eventually permit development of palliatives and cures for autoimmune diseases."-Journal of Investigational Allergology and Clinical Immunology

• Department of Pathology and Laboratory Medicine, Health Sciences Center, University of Texas Medical School, Houston, USA

  Sudhir Paul

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