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The 4-Quinolones: Anti Bacterial Agents in Vitro

Antibacterial Agents in Vitro

  • Book
  • © 1990

Overview

Editors:
  1. Geoff C. Crumplin

    1. Department of Biology, University of York, York, UK

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Part of the book series: Springer Series in Applied Biology (SSAPPL.BIOLOGY)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Quinolones as Broad-spectrum Agents

    1. Quinolones as Broad-spectrum Agents

      • H. C. Neu
      Pages 1-13

  3. Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency

    1. Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency

      • J. T. Smith
      Pages 15-21

  4. The Influence of Oxygen upon Bactericidal Potency

    1. The Influence of Oxygen upon Bactericidal Potency

      • I. Morrissey, C. S. Lewin, J. T. Smith
      Pages 23-36

  5. Interactions of 4-Quinolones with Other Agents — The Importance in Assessing Practical Antibacterial Potency

    1. Interactions of 4-Quinolones with Other Agents — The Importance in Assessing Practical Antibacterial Potency

      • C. S. Lewin, J. T. Smith
      Pages 37-51

  6. Molecular Effects of 4-Quinolones upon DNA Gyrase: DNA Systems

    1. Molecular Effects of 4-Quinolones upon DNA Gyrase: DNA Systems

      • G. C. Crumplin
      Pages 53-68

  7. Mechanisms of Killing of Bacteria by 4-Quinolones

    1. Mechanisms of Killing of Bacteria by 4-Quinolones

      • J. S. Wolfson, D. C. Hooper
      Pages 69-85

  8. Use of an In Vitro DNA Strand-Breakage Assay to Monitor Compound Interactions with DNA Gyrase

    1. Use of an In Vitro DNA Strand-Breakage Assay to Monitor Compound Interactions with DNA Gyrase

      • L. P. Elwell, L. M. Walton, J. M. Besterman, A. Hudson
      Pages 87-102

  9. Comparisons of DNA Gyrases from Different Species

    1. Comparisons of DNA Gyrases from Different Species

      • N. J. Robillard, B. L. Masecar, B. Brescia, R. Celesk
      Pages 103-114

  10. Structure-Activity Relationships of Fluoro-4-Quinolones

    1. Structure-Activity Relationships of Fluoro-4-Quinolones

      • L. A. Mitscher, P. V. Devasthale, R. M. Zavod
      Pages 115-146

  11. Aspects of Quinolone-DNA Interactions

    1. Aspects of Quinolone-DNA Interactions

      • L. L. Shen, J. Baranowski, M. Nuss, J. Tadanier, C. Lee, D. T. W. Chu et al.
      Pages 147-158

  12. Selective Toxicity: The Activities of 4-Quinolones against Eukaryotic DNA Topoisomerases

    1. Selective Toxicity: The Activities of 4-Quinolones against Eukaryotic DNA Topoisomerases

      • T. D. Gootz, J. F. Barrett, H. E. Holden, V. A. Ray, P. R. McGuirk
      Pages 159-172

  13. In Vitro Genotoxicity Assessment and the Effects of 4-Quinolones upon Human Cells

    1. In Vitro Genotoxicity Assessment and the Effects of 4-Quinolones upon Human Cells

      • G. C. Crumplin
      Pages 173-200

  14. Mechanisms of Resistance to 4-Quinolones

    1. Mechanisms of Resistance to 4-Quinolones

      • D. C. Hooper, J. S. Wolfson
      Pages 201-214

  15. In Vitro and In Vivo Mutation Frequencies to Resistance — do they Correlate in the Long Term?

    1. In Vitro and In Vivo Mutation Frequencies to Resistance — do they Correlate in the Long Term?

      • J. T. Smith
      Pages 215-227

  16. Measurement of the Frequency of Mutation to Resistance: The Importance of Testing under Physiological Conditions

    1. Measurement of the Frequency of Mutation to Resistance: The Importance of Testing under Physiological Conditions

      • M. Odell, G. C. Crumplin
      Pages 229-239

  17. Plasmid-Borne Resistance to 4-Quinolones a Real or Apparent Absence?

    1. Plasmid-Borne Resistance to 4-Quinolones a Real or Apparent Absence?

      • P. Courvalin, C. Poyart-Salmeron, E. Derlot
      Pages 241-248

  18. Poster Presentations

    1. Anaerobiosis and Staphylococcal Resistance to Certain 4-Quinolones

      • D. J. C. Knowles, G. T. Grimes, L. S. Holmes
      Pages 249-255

    2. Gram Negative Mutants Resistant to 4-Quinolones: Are they Competent Pathogens?

      • G. C. Crumplin
      Pages 257-268

    3. Quinolone-Resistant E. Coli Mutants Overproduce a 60 kDa Protein Highly Homologous to GroEL

      • P. Hallett, A. Mehlert, A. Maxwell
      Pages 269-273
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Keywords

About this book

The 4-quinolone antibacterial agents have been under development and in use for over 25 years, but despite an enormous body of research work there are still many basic questions that remain unanswered. For example, we do not know how these agents kill susceptible cells - or even how the drugs interact with the target mol- ecule(s). However, we do know that the 4-quinolones display many properties which are not shared with any other group of antibacterial agents. This book raises the unanswered questions and assesses the potential significance to future chemotherapy of their unique features. The book also raises matters which are significant for physicians as well as for the pharmaceutical industry and the assessment of these agents by legislative bodies concerned with drug safety.

Editors and Affiliations

  • Department of Biology, University of York, York, UK

    Geoff C. Crumplin

Bibliographic Information

  • Book Title: The 4-Quinolones: Anti Bacterial Agents in Vitro

  • Book Subtitle: Antibacterial Agents in Vitro

  • Editors: Geoff C. Crumplin

  • Series Title: Springer Series in Applied Biology

  • DOI: https://doi.org/10.1007/978-1-4471-3449-7

  • Publisher: Springer London

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag London Limited 1990

  • Softcover ISBN: 978-1-4471-3451-0Published: 12 April 2012

  • eBook ISBN: 978-1-4471-3449-7Published: 06 December 2012

  • Series ISSN: 1431-8539

  • Edition Number: 1

  • Number of Pages: XIV, 276

  • Topics: Microbiology, Medical Microbiology, Cell Biology

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