Cellular Engineering and Cellular Therapies

1. Front Matter

   Pages I-XIV

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2. Defining the Field

   1. Front Matter

      Pages 1-1

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   2. Cellular Engineering and Cellular Therapies — An Overview

      • L. F. M. H. de Leij, M. J. A. van Luyn, M. C. Harmsen

      Pages 3-10

   3. Gene Therapy 2002: A New Start

      • N. H. Mulder

      Pages 11-20

   4. Stem Cells: Potential, Selection and Plasticity

      • G. de Haan, A. Wiersema

      Pages 21-29

   5. The Potential of Stem Cell Transplantation to Rescue the Failing Liver

      • P. L. M. Jansen

      Pages 31-34

3. Processing Aspects

   1. Front Matter

      Pages 43-43

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   2. The New Regulatory Environment for Cellular Therapy Products: Challenges for Academic-Based Manufacturing Facilities

      • E. J. Read

      Pages 45-54

   3. Biological Modification of Lymphocytes in Auto- and Allo-Immune Diseases1

      • J. W. Semple, J. Freedman

      Pages 55-68

   4. Cell Harvest and Purification Technology — State of the Art and Future Development

      • P. Law

      Pages 69-80

   5. Cell Manipulation and Engineering — State of the Art and Future Developments

      • S. J. Noga

      Pages 81-87

   6. Cellular Immunotherapy — Towards Direct DC Activation for Licence to Kill

      • F. Ossendorp, S. van der Burg, R. Toes, R. Offringa, C. Melief

      Pages 89-94

4. Quality Aspects

   1. Front Matter

      Pages 109-109

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   2. From Research to Clinical Application-The Quality Concept

      • P. H. Roddie

      Pages 111-117

   3. Factors Controlling Expansion and Maturation of Haematopoietic Progenitor Cells

      • A. L. Drayer, E. Vellenga

      Pages 119-131

   4. Cell Processing for Gene and Cell Therapy Protocols: Limitations and Opportunities!

      • I. Slaper-Cortenbach, E. Simonetti, C. Arts, Ph. G. de Groot, A. van Dijk, S. Ebeling et al.

      Pages 133-138

5. Clinical Experiences and Prospect for Treatment

   1. Front Matter

      Pages 151-151

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   2. State of the Art in Dendritic Cell Vaccination

      • J. de Vries, G. J. Adema, C. J. A. Punt, C. G. Figdor

      Pages 153-159

   3. Reconstituting T Cell Immunity Following Hematopoietic Stem Cell Transplantation

      • S. R. Solomon, A. J. Barrett

      Pages 161-169

   4. State of the Art in Gene Therapy

      • H. J. Haisma, M. G. Rots

      Pages 171-187

Welcome to the City of Groningen, the center of the North of the Netherlands. Groningen is proud of the long lasting tradition of scientific symposia organised by the Sanquin Blood Bank. These Sanquin International Symposia on Blood Transfusion have become a true traditional event in Groningen, marking the early academic year and have contributed to the specific reputation of Groningen and its University in the scientific field of Transfusion Medicine. The growing tradition has also contributed to initiatives of both University, Province and the City of Groningen to bring science and industry together - BioMedCity Groningen. Such repu- tion does not just happen, but is the result of creative and scientific leadership, of vision and an open mind, to explore in a team spirit horizons. Groningen is particularly proud of this reputation thanks to its leadership, the Sanquin Blood Bank North-East. This year in particular the theme chosen some two years ago is extremely timely as it illustrates the activities and scientific interest of an integrated team which includes our regional Sanquin Blood Bank North-East and fits in the City initiatives within the concept of BioMedCity, Groningen.

• T cell
• blood
• blood cell
• cells
• diseases
• gene therapy
• hematopoietic stem cell
• hematopoietic stem cell transplantation
• immunotherapy
• lymphocytes
• stem cell transplantation
• stem cells
• transfusion medicine
• transplantation

• Sanquin Consulting Services, Groningen, The Netherlands

  C. Th. Smit Sibinga

• Groningen University Institute for Drug Exploration, Groningen, The Netherlands

  L. F. M. H. Leij

Policies and ethics