Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond

1. Front Matter

   Pages i-vi

   PDF

2. Structural Genomics by NMR Spectroscopy

   • Cheryl H. Arrowsmith

   Pages 1-11

3. Investigation of Proteins in Living Bacteria with In-Cell NMR Experiments

   • Volker Dötsch

   Pages 13-17

4. Protein-Membrane Interactions: Lessons from In Silico Studies

   • Roman G. Efremov, Pavel E. Volynsky, Anton A. Polyansky, Dmitry E. Nolde, Alexander S. Arseniev

   Pages 19-39

5. Anything Goes – Protein Structural Polymorphism

   • Angela M. Gronenborn

   Pages 41-47

6. Tandem Interactions in the trp Repressor System may Regulate Binding to Operator DNA

   • Oleg Jardetzky, Michael D. Finucane

   Pages 49-64

7. Basic Principles of RNA NMR Spectroscopy

   • Peter J. Lukavsky

   Pages 65-80

8. Probabilistic Structure Calculation

   • Wolfgang Rieping, Michael Habeck, Michael Nilges

   Pages 81-98

9. Molecular Insights into PKR Activation by Viral Double-Stranded RNA

   • Sean A. McKenna, Darrin A. Lindhout, Colin Echeverría Aitken, Joseph D. Puglisi

   Pages 99-110

10. Structural Dynamic Approach as Rational Input for Drug Design

    • Rotem Sertchook, Ariel Solomon, Tzvia Selzer, Irit Sagi

    Pages 111-120

11. Max Perutz: Chemist, Molecular Biologist, and Human Rights Activist

    • John Meurig Thomas

    Pages 121-126

12. Ribosomal Crystallography: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation

    • Ada Yonath

    Pages 127-153

13. Back Matter

    Pages 155-155

    PDF

This volume is a collection of articles from the Proceedings of the International School of Structural Biology and Magnetic Resonance 7th Course: Structure, Structure and Biophysics – New Technologies for Current Challenges in Biology and Beyond. This NATO Advance Study Institute (ASI) was held in Erice (Italy) at the Ettore Majorana Foundation and Centre for Scientific Culture on 22 June through 3 July 2005. The ASI brought together a diverse group of experts in the fields of structural biology, biophysics, and physics. Prominent lecturers, from seven different countries, and students from around the world participated in the NATO ASI organized by Professors Joseph Puglisi (Stanford University, California, USA) and Alexander Arseniev (Moscow, RU). Advances in nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography have allowed the thr- dimensional structures of many biological macromolecules and their complexes, including the ribosome and RNA polymerase to be solved. Fundamental principles of NMR spectroscopy and dynamics, X-ray crystallography, computation, and experimental dynamics were taught in the context of important biological applications. The ASI addressed the treatment and detection of bioterrorism agents, and focused on critical partner country priorities in biotechnology, materials, and drug discovery. The range of topics here represents the diversity of critical problems between structural biology, biochemistry, and biophysics, in which lies the fertile ground of drug development, biotechnology, and new materials. The individual articles represent the state of the art in each area and provide a guide to the original literature in this rapidly developing field.

• Biophysics
• Crystallography
• DNA
• Peptide
• X-ray
• biotechnology
• magnetic resonance

• Stanford Magnetic Resonance Laboratory, Stanford University School of Medicine, Stanford, USA

  Joseph D. Puglisi

Policies and ethics