Editors:
- First comprehensive book on Smad signal transduction
- Authored by the leading scientists in the field
- Includes supplementary material: sn.pub/extras
Part of the book series: Proteins and Cell Regulation (PROR, volume 5)
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Table of contents (22 chapters)
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Front Matter
About this book
For the first time world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic.
Reviews
From the reviews:
"This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. … This is definitely an ‘all-in’ book for those interested in or working on TGFß receptor signal transduction in general and Smad proteins in particular. … it is a must for all of us working in the field of TGFß signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007)
Editors and Affiliations
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Leiden University Medical Center, Leiden, The Netherlands
Peter ten Dijke
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Ludwig Institute for Cancer Research, Uppsala University, Sweden
Carl-Henrik Heldin
Bibliographic Information
Book Title: Smad Signal Transduction
Book Subtitle: Smads in Proliferation, Differentiation and Disease
Editors: Peter ten Dijke, Carl-Henrik Heldin
Series Title: Proteins and Cell Regulation
DOI: https://doi.org/10.1007/1-4020-4709-6
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2006
Hardcover ISBN: 978-1-4020-4542-4Published: 24 August 2006
Softcover ISBN: 978-90-481-7145-3Published: 22 November 2010
eBook ISBN: 978-1-4020-4709-1Published: 10 May 2007
Series ISSN: 1567-2530
Series E-ISSN: 2542-9973
Edition Number: 1
Number of Pages: XIV, 472
Topics: Life Sciences, general, Molecular Medicine, Cancer Research, Biochemistry, general, Cell Biology, Developmental Biology