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Green Chemistry in Drug Discovery

From Academia to Industry

  • Book
  • © 2022

Overview

Editors:
  1. Paul F. Richardson

    1. World Wide Medicinal Chemistry, Pfizer Inc., San Diego, USA

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  • Contains key implementation advice from the experts
  • Includes practical techniques
  • Provides step-by-step detail for reproducible results

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xvi
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  2. Greener Approaches to Classical Transformations

    1. Front Matter

      Pages 1-1
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    2. Green Synthesis of Common Heterocycles

      • Christian Schäfer, Hyejin Cho, Béla Török
      Pages 3-33

    3. Greener Methods for Amide Bond Synthesis

      • Nathan J. Oldenhuis, Aaron M. Whittaker, Vy M. Dong
      Pages 35-96

    4. Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications

      • Tsuyoshi Taniguchi
      Pages 97-122

    5. Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update

      • Pier Giorgio Cozzi, Andrea Gualandi, Luca Mengozzi, Elisabetta Manoni, Claire Margaret Wilson
      Pages 123-154

    6. Friedel-Crafts Reactions

      • Grigoriy Sereda
      Pages 155-178

    7. Ionic Liquids: Design and Applications

      • Arturo Obregón-Zúñiga, Eusebio Juaristi
      Pages 179-210

  3. Synthetic Strategy

    1. Front Matter

      Pages 211-211
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    2. Designing Efficient Cascade Reactions in Drug Discovery

      • Chenguang Yu, He Huang, Chunquan Sheng, Wei Wang
      Pages 213-235

    3. Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles

      • Razvan Cioc, Eelco Ruijter, Romano V. A. Orru
      Pages 237-267

    4. Direct C–H Functionalization Approaches to Pharmaceutically Relevant Molecules

      • James J. Mousseau, Antonia F. Stepan
      Pages 269-296

    5. C–H Activation with Photoredox Catalysis

      • Joel W. Beatty, Corey R. J. Stephenson
      Pages 297-325

    6. In Situ Protecting Groups for Chemoselective Transformations

      • Alan Steven
      Pages 327-372

  4. Enabling Technologies

    1. Front Matter

      Pages 373-373
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    2. Expanding the Biocatalysis Toolbox

      • Rajesh Kumar, Carlos A. Martinez, John W. Wong
      Pages 375-401

    3. New Directions in Coupling Chemistry

      • Gary M. Gallego, Rebecca A. Gallego, Paul F. Richardson
      Pages 403-487

    4. Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry

      • Nicholas E. Leadbeater
      Pages 489-526

    5. Reaction Optimization: A High-Throughput Experimentation Approach

      • Simon Berritt, Jason R. Schmink, Ana Inés Bellomo Peraza
      Pages 527-552

    6. Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry

      • Benjamin H. Rotstein, Neil Vasdev
      Pages 553-582
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Keywords

About this book

This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. 

Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist forthese techniques to be effectively implemented in the drug discovery process in a routine manner.

Editors and Affiliations

  • World Wide Medicinal Chemistry, Pfizer Inc., San Diego, USA

    Paul F. Richardson

About the editor

.

Bibliographic Information

  • Book Title: Green Chemistry in Drug Discovery

  • Book Subtitle: From Academia to Industry

  • Editors: Paul F. Richardson

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-0716-1579-9

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-1577-5Published: 14 December 2021

  • Softcover ISBN: 978-1-0716-2033-5Published: 14 December 2021

  • eBook ISBN: 978-1-0716-1579-9Published: 13 December 2021

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XVI, 617

  • Number of Illustrations: 590 b/w illustrations, 19 illustrations in colour

  • Topics: Pharmacology/Toxicology, Green Chemistry

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