Overview
- Editors:
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Wendy E. Walker
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Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, USA
- Includes cutting-edge techniques
- Provides step-by-step detail essential for reproducible results
- Contains key implementation advice from the experts
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Table of contents (20 protocols)
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Front Matter
Pages i-xiii
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- Susanne Drechsler, Marcin Osuchowski
Pages 1-8
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- Anna Herminghaus, Olaf Picker
Pages 9-15
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- Sailaja Ghanta, Min-Young Kwon, Mark A. Perrella
Pages 17-25
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- Jaimar C. Rincon, Philip A. Efron, Lyle L. Moldawer, Shawn D. Larson
Pages 27-41
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- Xian-Hui He, Dong-Yun Ouyang, Li-Hui Xu
Pages 43-51
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- Brian W. LeBlanc, Craig T. Lefort
Pages 53-61
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- Pilar Fajardo, Ana Cuenda, Juan José Sanz-Ezquerro
Pages 63-74
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- Charles T. Spencer, Mireya G. Ramos Muniz, Nicole R. Setzu, Michelle A. Sanchez Guillen
Pages 75-100
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- Belgacem Mihi, Wyatt E. Lanik, Qingqing Gong, Misty Good
Pages 101-110
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- Antonio Hernandez, Naeem K. Patil, Julia K. Bohannon
Pages 111-120
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- Tamara Merz, Sandra Kress, Michael Gröger, Peter Radermacher, Oscar McCook
Pages 121-135
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- Erica L. Heipertz, Wendy E. Walker
Pages 137-154
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- Takehiko Oami, Craig M. Coopersmith
Pages 169-175
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- Yachana Kataria, Daniel Remick
Pages 177-189
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- Dinesh G. Goswami, Wendy E. Walker
Pages 191-205
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- Yun Zhou, Yijia Yang, Dimitri Pappas
Pages 207-219
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- Christine A. Boehm, Jean A. Nemzek
Pages 221-229
About this book
This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical rodent models of sepsis, presented by experts in the field. In addition, the book includes protocols for burn injury and sepsis, modeling the mouse intensive care unit (MICU), and the development of humanized mice, which may be useful tools to increase the translational potential of rodent sepsis research. There is a chapter discussing the use of biomarkers for sepsis diagnosis and prognosis in humans and mice, as well as chapters describing specific methods for biomarker measurement, and the use of analgesics and humane endpoints in rodent sepsis research. Finally, agent-based computational modeling is presented as a valuable complementary approach to study sepsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Sepsis: Methods and Protocols serves as an ideal guide for researchers working toward improving the identification and treatment of septic patients.
Editors and Affiliations
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Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, USA
Wendy E. Walker
