Lung Cancer

1. Front Matter

   Pages i-xxi

   PDF

2. Introduction

   1. Characteristic Genetic Alterations in Lung Cancer

      • Ignacio I. Wistuba, Adi F. Gazdar

      Pages 3-28

3. Etiology and Classification of Lung Tumors

   1. Clinical and Biological Relevance of Recently Defined Categories of Pulmonary Neoplasia

      • Edward Gabrielson

      Pages 31-42

   2. Molecular Epidemiology of Human Cancer Risk

      • Kirsi Vähäkangas

      Pages 43-59

   3. Neuroendocrine Phenotype of Small Cell Lung Cancer

      • Judy M. Coulson, Marta Ocejo-Garcia, Penella J. Woll

      Pages 61-73

   4. AIDS-Associated Pulmonary Cancers

      • Kushagra Katariya, Richard J. Thurer

      Pages 75-86

4. Molecular Abnormalities in Lung Cancer

   1. Abrogation of the RB-p16Tumor Suppressor Pathway in Human Lung Cancer

      • Joseph Geradts

      Pages 89-99

   2. Sensitive Detection of Hypermethylated p16INK4a Alleles in Exfoliative Tissue Material

      • Marcus Schuermann, Michael Kersting

      Pages 101-109

   3. Role of Receptor Tyrosine Kinases in Lung Cancer

      • Gautam Maulik, Takashi Kijima, Ravi Salgia

      Pages 113-125

   4. Relationship of EGFR Signal-Transduction Modulation by Tyrosine Kinase Inhibitors to Chemosensitivity and Programmed Cell Death in Lung Cancer Cell Lines

      • Wendong Lei, Patrick P. Koty, Mark L. Levitt

      Pages 127-143

   5. Detection of the Transcripts and Proteins for the Transforming Growth Factor-β Isoforms and Receptors in Mouse Lung Tumorigenesis Using In Situ Hybridization and Immunohistochemistry in Paraffin-Embedded Tissue Sections

      • Sonia B. Jakowlew, Jennifer Mariano

      Pages 145-166

   6. Alterations in the Expression of Insulin-Like Growth Factors and Their Binding Proteins in Lung Cancer

      • Carrie M. Coleman, Adda Grimberg

      Pages 167-186

   7. Screening of Mutations in the ras Family of Oncogenes by Polymerase Chain Reaction-Based Ligase Chain Reaction

      • Alfredo MartÍnez, Teresa A. Lehman, Rama Modali, James L. Mulshine

      Pages 187-200

   8. Assays for Raf-1 Kinase Phosphorylation and Activity in Human Small Cell Lung Cancer Cells

      • Rajani K. Ravi, Barry D. Nelkin

      Pages 201-210

   9. γ-Glutamylcysteine Synthetase in Lung Cancer

      • Kristiina Järvinen, Ylermi Soini, Vuokko L. Kinnula

      Pages 211-222

   10. Localization of Cyclooxygenase-2 Protein Expression in Lung Cancer Specimens by Immunohistochemical Analysis

       • Sarah A. Wardlaw, Thomas H. March

       Pages 223-230

   11. Non-RI Protocols for L-myc Allelotyping and Deletion Mapping of Chromosome 1p in Primary Lung Cancers

       • Keiko Hiyama, Ciro Mendoza, Eiso Hiyama

       Pages 231-239

   12. Intercellular Adhesion Molecules (ICAM-1, VCAM-1, and LFA-1) in Adenocarcinoma of Lung

       • Armando E. Fraire, Bruce A. Woda, Louis Savas, Zhong Jiang

       Pages 243-249

   13. MUC1 Expression in Lung Cancer

       • Eva Szabo

       Pages 251-258

   14. Altered Surface Markers in Lung Cancer

       • Yoshihiro Nambu, David G. Beer

       Pages 259-266

The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research. Lung Cancer: Volume 1: Molecular Pathology Me- ods and Reviews presents an overview of the current status of assays employed to detect and characterize the multitude of pathologies that contribute to the development of this deadly disease. As with all volumes in the Methods in Molecular Medicine series, the reader should find that each methods-based chapter provides clear instructions for the performance of various protocols, supplemented by additional technical notes that provide valuable insight. These notes are designed to enable the reader to acquire the techniques described with a proficiency not easily achieved by re- ing standard method formats. No volume can exhaustively cover every aspect of biological research and there will be gaps in this endeavor that one or another research group will id- tify. Each section herein could readily be expanded into a book in its own right. However, I have sought to include a spectrum of techniques that should allow for the acquisition of key skills in each area covered.

• Children’s Hospital, Los Angeles, USA

  Barbara Driscoll

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