Current Controversies in Bone Marrow Transplantation

1. Front Matter

   Pages i-xiv

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2. Transplant Strategies

   1. Front Matter

      Pages 1-1

      PDF

   2. How Many Stem Cells Are Sufficient for Engraftment?

      • Lynn C. O’Donnell, Patrick J. Elder, Belinda R. Avalos

      Pages 3-27

   3. Is Bone Marrow Transplantation Appropriate in Older Patients?

      • Brian J. Bolwell

      Pages 29-39

   4. What Is an Accurate Risk/Benefit Ratio for Umbilical Cord Cell Transplantation in Children and Adults?

      • Mary J. Laughlin

      Pages 41-52

   5. Are Busulfan-Based Preparative Regimens Equivalent, Worse, or Better than Total Body Irradiation Regimens?

      • Edward A. Copelan

      Pages 53-67

   6. Is Total Body Irradiation Necessary in Bone Marrow Transplantation for Pediatric ALL?

      • Susan R. Wiersma, Susan B. Shurin

      Pages 69-80

3. Transplantation for Hematologic Malignancies

   1. Front Matter

      Pages 81-81

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   2. Stem Cell Transplantation for Chronic Myeloid Leukemia

      • Michael R. Bishop

      Pages 83-93

   3. Should All Adult Patients with Acute Lymphoblastic Leukemia in First Remission Undergo Allogeneic Bone Marrow Transplantation?

      • Sam L. Penza, Edward A. Copelan

      Pages 95-105

   4. What Is the Curative Potential of Refractory Leukemia with Related and Unrelated Allogeneic Transplants?

      • Matt E. Kalaycio

      Pages 107-117

   5. What Is the Role of Autologous Stem Cell Transplantation for Leukemia?

      • Selina M. Luger, Edward A. Stadtmauer

      Pages 119-135

   6. Autologous Transplantation for Hodgkin’s Disease

      • Craig H. Moskowitz, Stephen D. Nimer

      Pages 137-145

   7. Hematopoietic Stem Cell Transplantation for Mantle Cell Lymphoma

      • Brad Pohlman

      Pages 147-159

   8. Is Autologous Transplantation for Non-Hodgkin’s Lymphoma Underutilized?

      • Brian J. Bolwell

      Pages 161-174

4. Transplantation for Solid Tumors

   1. Front Matter

      Pages 175-175

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   2. Do Patients Benefit from Autotransplants for Advanced Ovarian Cancer?

      • Janet Ruzich, Patrick J. Stiff

      Pages 177-189

   3. What Is the Optimal Timing of Autologous Transplantation for Metastatic Breast Cancer?

      • Stephanie F. Williams

      Pages 191-197

   4. Should All Patients with Inflammatory Breast Cancer Undergo Autologous Stem Cell Transplant?

      • Beth A. Overmoyer

      Pages 199-215

   5. High-Dose Chemotherapy with Stem Cell Rescue for Germ Cell Cancer

      • E. Randolph Broun

      Pages 217-226

Leading transplant physicians critically review and interpret twenty-one key clinical challenges in bone marrow/hematopoietic cell transplantation, and offer their best personal recommendations for treatment. Topics range from transplant strategies to complications of bone marrow transplantation, including a discussion of the indications, benefits, and the risks for a variety of leukemias, lymphomas, and solid tumors. The authors debate such contentious issues as the appropriateness of transplants in older patients, how many stem cells are sufficient for engraftment, and the pros and cons of umbilical cord blood transplantation. Up-to-date and clinically focused, Current Controversies in Bone Marrow Transplantation offers clinical oncologists, hematology/oncology fellows in training, and residents in internal medicine today's best ready reference and management guide for all their critical oncologic problems arising from the use of bone marrow/stem cell transplantation.

• blood
• bone marrow
• cell
• hematology
• hematopoietic stem cell
• hematopoietic stem cell transplantation
• internal medicine
• leukemia
• lymphoma
• ovarian cancer
• prevention
• stem cell
• stem cell transplantation
• stem cells
• transplantation

"...this review of indications and results in the field is valuable and the expertise and opinions of the authors are clearly helpful in informing daily discussions on optimal available treatments for our patients."-Annals of Oncology

"This book makes a very valid attempt to unravel some of the many controversial issues which best the clinical practice of stem cell transplantation today....this book goes a long way to at least defining many of the problems that are encountered on a day-to-day basis in the context of stem cell transplantation, and sometimes even succeeds in answering them in the light of published studies.æ...the book makes excellent reading for all individuals involved in this specialized and technical field"-Bone Marrow Transplantation

"...this book is useful, with a few limitations, for every physician involved in the management of patients with transplant approach....this book is successful in general and represents the most useful snapshots of many current issues in the field of transplantation."- Journal of the National Cancer Institute

• Bone Marrow Transplant Program, Department of Hematology/Medical Oncology, The Cleveland Clinic Foundation, Cleveland, USA

  Brian J. Bolwell

Policies and ethics