The Sepsis Text

1. Front Matter

   Pages i-xx

   PDF

2. Generalities

   1. Sepsis: The Magnitude of the Problem

      • Jean-Louis Vincent

      Pages 1-9

   2. Diagnosis and Source of Sepsis: The Utility of Clinical Findings

      • Kenneth Cruz, R. Phillip Dellinger

      Pages 11-28

   3. Organ Failure

      • Rui Moreno, Ricardo Matos, Teresa Fevereiro

      Pages 29-46

   4. Markers of Sepsis

      • Heinz Redl, Andreas Spittler, Wolfgang Strohmaier

      Pages 47-66

   5. Genetic Predisposition

      • Frank Stüber

      Pages 67-79

   6. Quantifying Risk in Sepsis: A Review of Illness Severity and Organ Dysfunction Scoring

      • Randy S. Wax, Derek C. Angus, William Knaus

      Pages 81-96

3. Pathophysiology

   1. The Pathogenesis of Gram-Negative Sepsis

      • Christopher Papasian, David C. Morrison

      Pages 97-115

   2. The Pathophysiology of Gram-Positive Shock

      • R. Kate Beaton, Jonathan Cohen

      Pages 117-134

   3. Immunopathogenesis of Gram-Negative Shock

      • Steven M. Opal, Christian E. Hubert

      Pages 135-157

   4. Involvement of Pro- and Anti-Inflammatory Cytokines in Sepsis

      • Jean-Marc Cavaillon, Minou Adib-Conquy

      Pages 159-195

   5. Pathophysiology of Immunodepression in ICU Patients

      • Hans-Dieter Volk, Conny Höflich, Gerald Grütz, Wolf-Dietrich Döcke, Petra Reinke

      Pages 197-209

   6. Pathophysiology of Sepsis: The Role of Nitric Oxide

      • Simon Jonathan Finney, Timothy W Evans

      Pages 211-229

   7. Apoptosis and the Resolution of Inflammation in Sepsis

      • Geoffrey John Bellingan

      Pages 231-246

   8. Microvascular Alterations in Sepsis

      • Andreas W. Sielenkämper, Pete Kvietys, William J. Sibbald

      Pages 247-270

   9. Cytopathic Hypoxia

      • Mitchell P. Fink

      Pages 271-284

4. Monitoring Systems

   1. Invasive Hemodynamic Monitoring

      • Egbert Huettemann, Samir G. Sakka, Konrad Reinhart

      Pages 285-307

   2. Value of SvO ₂ in Sepsis

      • Thierry Boulain, Jean-Louis Teboul

      Pages 309-321

   3. Blood Lactate Concentrations in Sepsis

      • James A. Kruse

      Pages 323-338

   4. Veno-Arterial PCO2 Gradient

      • Vincent Castelain, Jean-Louis Teboul

      Pages 339-352

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.

• Sepsis
• antibiotics
• infection
• infections
• pathophysiology
• physiology
• infectious diseases

"The goald of the editors of The Sepsis Text was to provide a comprehensive review of recent achievements in the management of sepsis, based on basic and applied research performed in recent years by innovative scientists and clinical investigators worldwide ... excellent chapter on coagulation ...The editors and contributing authors should be congratulated for their excellent reviews of recent progress in our understanding of sepsis and in its management. The Sepsis Text clearly conveys their enthusiasm and provides encouragement to all those working in the field."
(Greet Van den Berghe, Catholic University of Leuven in The New England Journal of Medicine, 347:15 (2002)

• Department of Intensive Care, Erasme University Hospital, Brussels, Belgium

  Jean-Louis Vincent

• Service de Réanimation Polyvalente, Hôpital Saint-Joseph, Paris, France

  Jean Carlet

• Division of Infectious Diseases, The Memorial Hospital of Rhode Island, Pawtucket

  Steven M. Opal

Policies and ethics