Imaging of Hypoxia

1. Front Matter

   Pages i-xx

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2. Hypoxia: an Introduction

   • Leonard I. Wiebe, Hans-Jürgen Machulla

   Pages 1-18

3. The Biology of Technetium Based Hypoxic Tissue Localising Compounds

   • Adrian D. Nunn

   Pages 19-45

4. Basic Chemistry of 2-Nitroimidazoles (Azomycin Derivatives)

   • Christa E. Müller

   Pages 47-59

5. Molecular Design Approaches of Hypoxia Tracers

   • Gerd Folkers, Frank Alber, Oliver Kuonen, Alfred Merz

   Pages 61-74

6. Syntheses of PET-Tracers for the Determination of Hypoxia

   • John Grierson, Marianne Patt

   Pages 75-84

7. Quantifying Hypoxia with Radiolabeled Fluoromisonidazole: Pre-Clinical and Clinical Studies

   • Janet S. Rasey, Gary V. Martin, Kenneth A. Krohn

   Pages 85-117

8. Detection of Liver Hypoxia by [18F]Fluoromisonidazole and Application in Liver Transplant Disorders

   • Morand Piert, Hans-Jürgen Machulla

   Pages 119-127

9. The Evaluation of Hypoxia in Diabetes

   • John R. Mercer, Hui Liu

   Pages 129-153

10. Radiohalogenated Nitroimidazoles for Single-photon Scintigraphic Imaging of Hypoxic Tissues

    • Leonard I. Wiebe

    Pages 155-176

11. Back Matter

    Pages 177-180

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Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem.
As the result of a workshop held by the Section for Radiopharmacy in Tübingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.

• SPECT
• Tumor
• cardiology
• imaging
• neurology
• organ transplantation
• positron emission tomography (PET)
• radiation
• transplantation
• Radiaton Oncology

`Overall, this text provides a summary of the status of radionuclide imaging of hypoxia. The material is clearly prestented, well referenced and authoritative. The text is concise, and should serve as a reference for investigators interested in pursuing work in this field.'
European Journal of Nuclear Medicine 28:5,(2001)

• Section Radiopharmacy, Interdisciplinary PET-Center, Eberhard-Karls University, Tübingen, Germany

  Hans-Jürgen Machulla

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