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  • © 1992

Kinetics and Dynamics of Intravenous Anesthetics

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Part of the book series: Developments in Critical Care Medicine and Anaesthesiology (DCCA, volume 26)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
  2. Basic Mathematical Principles

    • Gerald M. Woerlee
    Pages 1-22
  3. Multicompartment Kinetic Models

    • Gerald M. Woerlee
    Pages 55-86
  4. Pharmacodynamics

    • Gerald M. Woerlee
    Pages 87-115
  5. Practical I.V. Bolus Kinetics & Dynamics

    • Gerald M. Woerlee
    Pages 116-147
  6. Intravenous Infusions

    • Gerald M. Woerlee
    Pages 148-168
  7. Body Weight and Composition

    • Gerald M. Woerlee
    Pages 169-179
  8. Plasma Protein Binding

    • Gerald M. Woerlee
    Pages 180-187
  9. Cardiac Output

    • Gerald M. Woerlee
    Pages 188-192
  10. Age

    • Gerald M. Woerlee
    Pages 193-201
  11. Obesity

    • Gerald M. Woerlee
    Pages 202-208
  12. Pregnancy Related Problems

    • Gerald M. Woerlee
    Pages 209-216
  13. Renal Failure

    • Gerald M. Woerlee
    Pages 217-225
  14. Hepatic Dysfunction

    • Gerald M. Woerlee
    Pages 226-231
  15. Back Matter

    Pages 233-253

About this book

Many drugs used in current anesthetic practice are administered intravenously. An appreciation of their kinetics and dynamics is of great assistance in determining the most appropriate drug to use, and optimal dosage regimens for any given patient.
This book is specially oriented to the requirements of anesthesiologists. It will enable the student of those subjects to gain enough knowledge to make these subjects usable in daily anesthetic practice. As such it is intermediate in difficulty between mathematically oriented texts, and those which only offer a very qualitative understanding of these subjects. Practical applications and examples of the uses to which kinetic and dynamic principles can be put in daily practice are emphasized and illustrated. Basic principles and techniques with which the reader can perform kinetic and dynamic calculations are explained simply and demonstrated in detail using examples derived from clinical practice. Two appendices provide kinetic and dynamic data on the most commonly used anesthetic drugs.
The last chapters use the principles discussed in the first chapters to show how variations of normal physiology and disease affect drug kinetics and dynamics. This is especially valuable to the clinician as it enables clinically useful, albeit qualitative, predictions to be made of the direction of any change of kinetic and dynamic parameters of drugs due to these factors.

Authors and Affiliations

  • Rijnoord Hospital, Alphen aan den Rijn, The Netherlands

    Gerald M. Woerlee

Bibliographic Information

  • Book Title: Kinetics and Dynamics of Intravenous Anesthetics

  • Authors: Gerald M. Woerlee

  • Series Title: Developments in Critical Care Medicine and Anaesthesiology

  • DOI: https://doi.org/10.1007/978-0-585-28009-7

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1992

  • Softcover ISBN: 978-94-017-4097-5Published: 03 October 2013

  • eBook ISBN: 978-0-585-28009-7Published: 11 July 2007

  • Series ISSN: 0924-5294

  • Edition Number: 1

  • Number of Pages: XI, 256

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Anesthesiology, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access