Epidemiology and Biostatistics

1. Front Matter

   Pages i-xiii

   PDF

2. Epidemiology

   1. Front Matter

      Pages 1-1

      PDF

   2. Measures of Disease Frequency

      • Bryan Kestenbaum

      Pages 3-12

   3. General Considerations in Clinical Research Design

      • Bryan Kestenbaum

      Pages 13-24

   4. Case Reports and Case Series

      • Bryan Kestenbaum

      Pages 25-27

   5. Cross-Sectional Studies

      • Bryan Kestenbaum

      Pages 29-31

   6. Cohort Studies

      • Bryan Kestenbaum

      Pages 33-44

   7. Case-Control Studies

      • Bryan Kestenbaum

      Pages 45-57

   8. Randomized Trials

      • Bryan Kestenbaum

      Pages 59-73

   9. Misclassification

      • Bryan Kestenbaum

      Pages 75-89

   10. Introduction to Confounding

       • Bryan Kestenbaum

       Pages 91-100

   11. Methods to Control for Confounding

       • Bryan Kestenbaum

       Pages 101-111

   12. Effect Modification

       • Bryan Kestenbaum

       Pages 113-120

   13. Screening

       • Bryan Kestenbaum

       Pages 121-138

   14. Diagnostic Testing

       • Bryan Kestenbaum

       Pages 139-150

3. Biostatistics

   1. Front Matter

      Pages 152-152

      PDF

   2. Summary Measures in Statisitics

      • Abigail B. Shoben

      Pages 153-162

   3. Introduction to Statistical Inference

      • Bryan Kestenbaum

      Pages 163-170

   4. Hypothesis Testing

      • Bryan Kestenbaum

      Pages 171-180

   5. Interpreting Hypothesis Tests

      • Abigail B. Shoben

      Pages 181-187

This textbook was born from a disparate collection of written materials that were created to teach Epidemiology and Biostatistics to second year medical students at the University of Washington. These materials included handouts, practice problems, guides to reading research articles, quizzes, notes from student help sessions, and student emails. The primary goal of these written materials, and now this book, is to recreate the perspective of learning Epidemiology and Biostatistics for the first time. With critical editing assistance from Epidemiology faculty, graduate students in Epidemiology and Biostatistics, and the students themselves, I have tried to preserve the innate logic and connectedness of clinical research methods and to demonstrate their application. The textbook is designed to provide students with the tools necessary to form their own informed conclusions from the clinical research literature. More than ever, a clear understanding of the fundamental aspects of Epidemiology and Biostatistics is needed to successfully navigate the increasingly complex methods utilized by modern clinical research studies. This book could not have been created without the dedicated help of the e- tors, the teaching assistants, and the students, who asked the important questions. I would especially like to thank my family who patiently allowed me so much time to write.

• Biostatistics
• Clinical Research Design
• Epidemiology
• Public Health
• Statistics in Clinical Research
• Survival analysis
• classification
• epidemiological
• linear regression
• statistics

From the reviews:

"In this introductory textbook, examples are carefully chosen to help readers understand important concepts in epidemiology and biostatistics, as well as their application to the field of clinical research. … the book will be useful to any healthcare practitioner interested in having a better understanding of clinical research. … This book has the important quality of providing students with an introductory overview that not only helps them understand the methods, but also guides those interested in learning more in the right direction." (Daniela Claudia Moga, Doody’s Review Service, November, 2009)

“This concise introductory textbook was ‘born from a disparate collection of written materials that were created to teach epidemiology and biostatistics to second-year medical students.’ … to provide medical students with a basic instruction to clinical epidemiology and biostatistics … . suitable for … students with no previous background in clinical epidemiology or biostatistics and for practitioners who want concise introduction to facilitate interpretation of the medical literature. … serve as the course text for a medical student introduction to clinical research methods.” (Douglas J. Lanska, Journal of the American Medical Association, Vol. 303 (18), 2010)

• Harborview Medical Center, University of Washington, Seattle, U.S.A.

  Bryan Kestenbaum

Dr. Kestenbaum is an Assistant Professor, Department of Medicine, Division of Nephrology, at the University of Washington.

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