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  • Book
  • © 2006

Bioinformatics of Genome Regulation and Structure II

  • Comprises the newest results obtained while researching into the structure and function of molecular genetic systems belonging to different complexity level of their organization

  • Covers the hottest items in bioinformatics

  • Includes supplementary material: sn.pub/extras

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Table of contents (47 chapters)

  1. Front Matter

    Pages i-xvi
  2. Computational Structural, Functional and Evolutionary Genomics

    1. Front Matter

      Pages 1-1
    2. Recognition of Coding Regions in Genome Alignment

      • T. V. Astakhova, S. V. Petrova, I. I. Tsitovich, M. A. Roytberg
      Pages 3-10
    3. Predicting sRNA Genes in the Genome of E. Coli by the Promoter-Search Algorithm PlatProm

      • A. S. Brok-Volchanski, I. S. Masulis, K. S. Shavkunov, V. I. Lukyanov, Yu. A. Purtov, E. G. Kostyanicina et al.
      Pages 11-20
    4. Transcription Regulatory Regions Database (TRRD): A Source of Experimentally Confirmed Data on Transcription Regulatory Regions of Eukaryotic Genes

      • N. Kolchanov, E. Ignatieva, O. Podkolodnaya, E. Ananko, I. Stepanenko, T. Merkulova et al.
      Pages 43-53
    5. Artsite Database: Comparison of In Vitro Selected and Natural Binding Sites of Eukaryotic Transcription Factors

      • T. Khlebodarova, O. Podkolodnaya, D. Oshchepkov, D. Miginsky, E. Ananko, E. Ignatieva
      Pages 55-65
    6. Comparative Analysis of Electrostatic Patterns for Promoter and Nonpromoter DNA in E. Coli Genome

      • S. G. Kamzolova, A. A. Sorokin, P. M. Beskaravainy, A. A. Osypov
      Pages 67-74
    7. Analysis of Nucleosome Formation Potential and Conformational Properties of Human J1-J2 and D2-D1 Type Alpha Satellite DNA

      • A. Katokhin, V. Levitsky, D. Oshchepkov, A. Poplavsky, V. Trifonov, D. Furman
      Pages 75-83
    8. VMM: A Variable Memory Markov Model Prediction of Nucleosome Formation Sites

      • Yu. L. Orlov, V. G. Levitsky, O. G. Smirnova, O. A. Podkolodnaya, T. M. Khlebodarova, N. A. Kolchanov
      Pages 85-95
    9. DNA Nucleosome Organization of the Promoter Gene Regions

      • V. G. Levitsky, A. G. Pichueva, A. V. Kochetov, L. Milanesi
      Pages 97-103
    10. A Toolbox for Analysis of RNA Secondary Structure Based on Genetic Algorithm

      • I. Titov, D. Vorobiev, A. Palyanov
      Pages 105-110
    11. Comparative Genomics and Evolution of Bacterial Regulatory Systems

      • M. S. Gelfand, A. V. Gerasimova, E. A. Kotelnikova, O. N. Laikova, V. Y. Makeev, A. A. Mironov et al.
      Pages 111-119
    12. Comparative Whole Genome Sequence Analysis of Corynebacteria

      • Y. Nishio, Y. Usuda, T. Gojobori, K. Ikeo
      Pages 121-129
    13. New LTR Retrotransposable Elements from Eukaryotic Genomes

      • O. Novikova, M. Fursov, E. Beresikov, A. Blinov
      Pages 131-140
    14. A Genome-Wide Identification of Mitochondrial DNA Topoisomerase I in Arabidopsis

      • A. Katyshev, I.B. Rogozin, Yu. Konstantinov
      Pages 141-145
    15. New Methods to Infer DNA Function from Sequence Information

      • I. Abnizova, R. te Boekhorst, K. Walter, W. R. Gilks
      Pages 165-177

About this book

The last 15 years in development of biology were marked with accumulation of unprecedentedly huge arrays of experimental data. The information was amassed with exclusively high rates due to the advent of highly efficient experimental technologies that provided for high throughput genomic sequencing; of functional genomics technologies allowing investigation of expression dynamics of large groups of genes using expression DNA chips; of proteomics methods giving the possibility to analyze protein compositions of cells, tissues, and organs, assess the dynamics of the cell proteome, and reconstruct the networks of protein-protein interactions; and of metabolomics, in particular, high resolution mass spectrometry study of cell metabolites, and distribution of metabolic fluxes in the cells with a concurrent investigation of the dynamics of thousands metabolites in an individual cell. Analysis, comprehension, and use of the tremendous volumes of experimental data reflecting the intricate processes underlying the functioning of molecular genetic systems are unfeasible in principle without the systems approach and involvement of the state-of-the-art information and computer technologies and efficient mathematical methods for data analysis and simulation of biological systems and processes. The need in solving these problems initiated the birth of a new science— postgenomic bioinformatics or systems biology in silico.

Editors and Affiliations

  • Institute of Cytology & Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

    Nikolay Kolchanov

  • Bielefeld University, Bielefeld, Germany

    Ralf Hofestaedt

  • CNR-ITB Institute of Biomedical Technologies, Segrate (Milano), Italy

    Luciano Milanesi

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access