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DNA Methylation and Cancer Therapy

  • Book
  • © 2005

Overview

Authors:
  1. Moshe Szyf

    1. Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada

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  • DNA Methylation and Cancer Theraphy focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials.
  • The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Medical Intelligence Unit (MIUN)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. DNA Methylation

    • Aharon Razin
    Pages 1-12

  3. Epigenetic Mechanisms of Gene Regulation

    • Keith D. Robertson
    Pages 13-30

  4. DNA Hypo- vs. Hypermethylation in Cancer

    • Melanie Ehrlich, Guanchao Jiang
    Pages 31-41

  5. DNA Methylation in Urological Cancers

    • Wolfgang A. Schulz, Hans-Helge Seifert
    Pages 42-58

  6. DNA Methylation in Colorectal Cancer

    • Jeremy R. Jass, Vicki L. J. Whitehall, Joanne Young, Barbara A. Leggett
    Pages 59-68

  7. CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer

    • Michel Herranz, Manel Esteller
    Pages 69-84

  8. The Loss of Methyl Groups in DNA of Tumor Cells and Tissues

    • Alain Niveleau, Chandrika Piyathilake, Adriana de Capoa, Claudio Grappelli, Jean-Marc Dumollard, Lucien Frappart et al.
    Pages 85-106

  9. Identifying Clinicopathological Association of DNA Hypermethylation in Cancers Using CpG Island Microarrays

    • Susan H. Wei, Timothy T. -C. Yip, Chuan-Mu Chen, Tim H. -M. Huang
    Pages 107-116

  10. Methylation Analysis in Cancer

    • Carolina Haefliger, Sabine Maier, Alexander Olek
    Pages 117-124

  11. Regulation of DNA Methyltransferases in Cancer

    • Nancy Detich, Moshe Szyf
    Pages 125-141

  12. Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation

    • Anna Reale, Giuseppe Zardo, Maria Malanga, Jordanka Zlatanova, Paola Caiafa
    Pages 142-155

  13. The Role of Active Demethylation in Cancer and Its Therapeutic Potential

    • Moshe Szyf, Paul M. Campbell, Nancy Detich, Jing Ni Ou, Stefan Hamm, Veronica Bovenzi
    Pages 156-177

  14. Purine Analogues and Their Role in Methylation and Cancer Chemotherapy

    • Katherine L. Seley, Sylvester L. Mosley
    Pages 178-186

  15. DNA Methyltransferase Inhibitors

    • Gregory K. Reid, A. Robert MacLeod
    Pages 187-204

  16. Preclinical and Clinical Studies on 5-Aza-2′-Deoxycytidine, a Potent Inhibitor of DNA Methylation, in Cancer Therapy

    • Richard L. Momparler
    Pages 205-217

  17. Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense

    • Pascal Bigey, Daniel Scherman
    Pages 218-229

  18. Epilogue

    • Moshe Szyf
    Pages 230-233

  19. Back Matter

    Pages 235-239
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Keywords

About this book

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo­ Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me­ thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat­ terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac­ tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

Authors and Affiliations

  • Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada

    Moshe Szyf

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