Nitric Oxide and Infection

1. Front Matter

   Pages i-xxv

   PDF

2. Introduction

   1. An Overview of Nitric Oxide in Infection

      • Ferric C. Fang

      Pages 3-9

3. Historical Aspects of Nitric Oxide

   1. The Discovery of the Biological Synthesis of Nitric Oxide

      • Jonh B. Hibbs Jr., Neil R. Bastian

      Pages 13-33

4. Biological Roles of Nitric Oxide

   1. Biochemistry of Nitric Oxide

      • Benjamin Gaston, Jonathan S. Stamler

      Pages 37-55

   2. Enzymology of Nitric Oxide Biosynthesis

      • Benjamin Hemmens, Bernd Mayer

      Pages 57-76

   3. Cytokine Regulation of Nitric Oxide Production

      • Heiko Mühl, Charles A. Dinarello

      Pages 77-94

   4. Human Mononuclear Phagocyte Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression

      • J. Brice Weinberg

      Pages 95-150

   5. Cardiovascular Actions of Nitric Oxide

      • Daryl D. Rees

      Pages 151-174

   6. Biochemical Regulation of Nitric Oxide Cytotoxicity

      • Andrew J. Gow, Raymond Foust III, STuart Malcolm, Madhura Gole, Harry Ischiropoulos

      Pages 175-187

   7. Cytoprotective Effects of NO against Oxidative Injury

      • David A. Wink, Yoram Vodovotz, Willliam DeGraff, John A. Cook, Roberto Pacelli, Murali Krishna et al.

      Pages 189-198

   8. Immunomodulatory Actions of Nitric Oxide

      • Iain B. McInnes, Foo Y. Liew

      Pages 199-213

   9. Nitric Oxide and Epithelial Host Defense

      • Nigel Benjamin, Roelf Dykhuizen

      Pages 215-230

   10. Antimicrobial Properties of Nitric Oxide

       • Mary Ann DeGroote, Ferric C. Fang

       Pages 231-261

5. Nitric Oxide in Specific Infections

   1. Nitric Oxide in Sepsis

      • Gillian Wray, Christoph Thiemermann

      Pages 265-280

   2. Nitric Oxide in Mycobacterium tuberculosis Infection

      • John Chan, Janne Flynn

      Pages 281-307

   3. Nitric Oxide in Malaria

      • Nicholas M. Anstey, J. Brice Weinberg, Donald L. Granger

      Pages 311-341

   4. Nitric Oxide in Schistosomiasis

      • Isabelle P. Oswald

      Pages 343-360

   5. Nitric Oxide in Leishmaniasis

      • Christian Bogdan, Martin Röllinghoff, Andreas Diefenbach

      Pages 361-377

   6. Nitric Oxide in Viral Myocarditis

      • Charles J. Lowenstein, Marta Saura, Carlos Zaragoza

      Pages 379-396

   7. Nitric Oxide in Influenza

      • Takaaki Akaike, Hiroshi Maeda

      Pages 397-415

Familiarity with nitric oxide is essential to a modern understanding of pathophysiologic mechanisms of infectious disease. Recent research has established nitric oxide and related reactive nitrogen intermediates to be important molecular mediators of diverse physiologic processes such as control of vascular tone, regulation of the immune system, and microbial and tumor cell growth. This book contains chapters by the leading researchers in the field and examines the biology and biochemistry of nitric oxide and its role in a variety of specific infections ranging from sepsis, tuberculosis and malaria to viral myocarditis, influenza, and AIDS.

• AIDS
• Malaria
• Schistosomiasis
• Sepsis
• antimicrobial
• bacteria
• cardiovascular
• cardiovascular actions
• infection
• infections
• infectious
• infectious disease
• infectious diseases

• University of Colorado Health Sciences Center, Denver

  Ferric C. Fang

Policies and ethics