Biology and Physiology of the Blood-Brain Barrier

1. Front Matter

   Pages i-xvi

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2. Introductory Overviews

   1. Development of Blood-Brain Barrier Endothelial Cells

      • Werner Risau

      Pages 1-7

   2. Prospects for Neuroprotective Gene Therapy for Neurodegenerative Diseases

      • Marc Peschanski

      Pages 9-10

3. Physiological Transports through the Blood-Brain Barrier

   1. Blood-Brain Barrier Taurine Transport and Brain Volume Regulation

      • Richard F. Keep, Walter Stummer, Jianming Xiang, A. Lorris Betz

      Pages 11-16

   2. Volume Regulation of the in Vitro Blood-Brain Barrier by Osmoreactive Amino Acids during Stress

      • P. J. Gaillard, A. G. De Boer, D. D. Breimer

      Pages 17-19

   3. A Reduction in the Transfer of Amino Acids Across the Blood-Brain Barrier Might Not be the Sole Mechanism by Which Vasopressin Affects Amino Acid Levels within the Brain

      • A. Reichel, D. J. Begley, A. Ermisch

      Pages 21-26

   4. Differential Amino Acid Uptake into Cerebral Parenchyma and Capillary Cells during Development

      • Hameed Al-Sarraf, Kevin A. Smart, Malcolm B. Segal, Jane E. Preston

      Pages 27-33

   5. Transport of ³H L-Alanine Across the Blood-Brain Barrier of in Situ Perfused Guinea Pig Brain

      • Ivanka D. Markovic, Zoran B. Redzic, Suzana S. Jovanovic, Dusan M. Mitrovic, Ljubisa M. Rakic

      Pages 35-39

   6. Distribution of Small Neutral Amino Acids after Penetrating the Luminal Side of the Guinea Pig Blood-Brain Barrier

      • S. S. Jovanovic, Z. B. Redzic, I. D. Markovic, D. M. Mitrovic, Lj. M. Rakic

      Pages 41-45

   7. The Blood-Brain Barrier, Potassium, and Brain Growth

      • Richard F. Keep, Jianming Xiang, A. Lorris Betz

      Pages 47-50

   8. Receptor-Mediated Transcytosis of Transferrin through Blood-Brain Barrier Endothelial Cells

      • Laurence Descamps, Marie-Pierre Dehouck, Gérard Torpier, Roméo Cecchelli

      Pages 51-54

   9. Intracerebral Expression of Transferrin Receptors in Iron-Deficient Rats

      • T. Moos, T. M. Hansen

      Pages 55-61

   10. Vascular Permeability to Hemorphins in the Central Nervous System

       • H. S. Sharma, K. Sanderson, E.-L. Glämsta, Y. Olsson, F. Nyberg

       Pages 63-68

   11. The Effect of Glycosylation on the Uptake of an Enkephalin Analogue into the Central Nervous System

       • Sarah A. Williams, Thomas J. Abbruscato, Lajos Szabo, Robin Polt, Victor Hruby, Thomas P. Davis

       Pages 69-77

   12. Blood-Retina Barrier Properties of the Pecten Oculi of the Chicken

       • Holger Gerhardt, Stefan Liebner, Hartwig Wolburg

       Pages 79-81

4. Blood-Brain Barrier and Drug Delivery to the Brain

   1. The Microarchitecture of Cerebral Vessels

      • Kenneth R. Davies, Grace Richardson, Wendy Akmentin, Virgil Acuff, Joseph D. Fenstermacher

      Pages 83-91

   2. Development of Blood-Brain Barrier Tight Junctions

      • Uwe Kniesel, Werner Risau, Hartwig Wolburg

      Pages 93-95

   3. Membrane Fractionation of Brain Capillary Endothelial Cells and Analysis of Lipid Polarity

      • Bernhard J. Tewes, Hans-Joachim Galla

      Pages 97-101

   4. “Brain-Tissue-Specific” Versus “Serum-Specific” Posttranslational Modification of Human Cerebrospinal Fluid Polypeptides with N-Linked Carbohydrates

      • Andrea Hoffmann, Eckart Grabenhorst, Manfred Nimtz, Harald S. Conradt

      Pages 103-107

   5. Blood-Brain Barrier Properties in Vitro as Related to the Neurotransmitter Serotonin

      • P. Brust, S. Matys, J. Wober, A. Friedrich, R. Bergmann, B. Ahlemeyer

      Pages 109-115

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho­ logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu­ dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

• Nervous System
• Pathologie
• development
• neuroscience
• physiology

• Institut Cochin de Génétique Moléculaire, Paris, France

  Pierre-Olivier Couraud

• CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France

  Daniel Scherman

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